Good Ol' Fat: Links between Lipid Signaling and Longevity

被引：41

作者：

Bustos, Victor ^{[1
]}

Partridge, Linda ^{[1
,2
]}

机构：

[1] Max Planck Inst Biol Ageing, Joseph Stelzmann Str 9b, D-50931 Cologne, Germany

[2] UCL, Dept Genet Evolut & Environm, Inst Hlth Ageing, Darwin Bldg,Gower St, London WC1E 6BT, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2017年 / 42卷 / 10期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

ELEGANS LIFE-SPAN; CALORIC RESTRICTION; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; NUCLEAR RECEPTOR; C.-ELEGANS; REGULATES CHOLESTEROL; ADIPOSE-TISSUE; METABOLISM; INSULIN;

D O I：

10.1016/j.tibs.2017.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling. In this review we summarize accumulating evidence that points to changes in lipid metabolism, and in particular lipid signaling, as an underlying mechanism for healthy aging.

引用

页码：812 / 823

页数：12

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