RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms

被引:347
作者
Hao, Zhaodong [1 ,2 ]
Lv, Dekang [3 ]
Ge, Ying [3 ]
Shi, Jisen [1 ]
Weijers, Dolf [2 ]
Yu, Guangchuang [4 ]
Chen, Jinhui [1 ]
机构
[1] Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Minist Educ, Key Lab Forest Genet & Biotechnol, Nanjing, Jiangsu, Peoples R China
[2] Wageningen Univ, Lab Biochem, Haarlem, Netherlands
[3] Dalian Med Univ, Inst Canc Stem Cell, Dalian, Liaoning, Peoples R China
[4] Southern Med Univ, Sch Basic Med Sci, Inst Bioinformat, Guangzhou, Guangdong, Peoples R China
关键词
Genome; Chromosome; Idiogram; R package; Data visualization;
D O I
10.7717/peerj-cs.251
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Background. Owing to the rapid advances in DNA sequencing technologies, whole genome from more and more species are becoming available at increasing pace. For whole-genome analysis, idiograms provide a very popular, intuitive and effective way to map and visualize the genome-wide information, such as GC content, gene and repeat density, DNA methylation distribution, genomic synteny, etc. However, most available software programs and web servers are available only for a few model species, such as human, mouse and fly, or have limited application scenarios. As more and more non-model species are sequenced with chromosome-level assembly being available, tools that can generate idiograms for a broad range of species and be capable of visualizing more data types are needed to help better understanding fundamental genome characteristics. Results. The R package RIdeogram allows users to build high-quality idiograms of any species of interest. It can map continuous and discrete genome-wide data on the idiograms and visualize them in a heat map and track labels, respectively. Conclusion. The visualization of genome-wide data mapping and comparison allow users to quickly establish a clear impression of the chromosomal distribution pattern, thus making RIdeogram a useful tool for any researchers working with omics.
引用
收藏
页码:1 / 11
页数:11
相关论文
共 28 条
[1]  
Anand L., 2019, CHROMOMAP INTERACTIV, DOI [10.1101/605600, DOI 10.1101/605600]
[2]  
[Anonymous], 2018, R LANG ENV STAT COMP
[3]   The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution [J].
Badouin, Helene ;
Gouzy, Jerome ;
Grassa, Christopher J. ;
Murat, Florent ;
Staton, S. Evan ;
Cottret, Ludovic ;
Lelandais-Briere, Christine ;
Owens, Gregory L. ;
Carrere, Sebastien ;
Mayjonade, Baptiste ;
Legrand, Ludovic ;
Gill, Navdeep ;
Kane, Nolan C. ;
Bowers, John E. ;
Hubner, Sariel ;
Bellec, Arnaud ;
Berard, Aurelie ;
Berges, Helene ;
Blanchet, Nicolas ;
Boniface, Marie-Claude ;
Brunel, Dominique ;
Catrice, Olivier ;
Chaidir, Nadia ;
Claudel, Clotilde ;
Donnadieu, Cecile ;
Faraut, Thomas ;
Fievet, Ghislain ;
Helmstetter, Nicolas ;
King, Matthew ;
Knapp, Steven J. ;
Lai, Zhao ;
Le Paslier, Marie-Christine ;
Lippi, Yannick ;
Lorenzon, Lolita ;
Mandel, Jennifer R. ;
Marage, Gwenola ;
Marchand, Gwenaelle ;
Marquand, Elodie ;
Bret-Mestries, Emmanuelle ;
Morien, Evan ;
Nambeesan, Savithri ;
Thuy Nguyen ;
Pegot-Espagnet, Prune ;
Pouilly, Nicolas ;
Raftis, Frances ;
Sallet, Erika ;
Schiex, Thomas ;
Thomas, Justine ;
Vandecasteele, Celine ;
Vares, Didier .
NATURE, 2017, 546 (7656) :148-+
[4]   Rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology [J].
Cao, Hongzhi ;
Hastie, Alex R. ;
Cao, Dandan ;
Lam, Ernest T. ;
Sun, Yuhui ;
Huang, Haodong ;
Liu, Xiao ;
Lin, Liya ;
Andrews, Warren ;
Chan, Saki ;
Huang, Shujia ;
Tong, Xin ;
Requa, Michael ;
Anantharaman, Thomas ;
Krogh, Anders ;
Yang, Huanming ;
Cao, Han ;
Xu, Xun .
GIGASCIENCE, 2014, 3
[5]   Liriodendron genome sheds light on angiosperm phylogeny and species-pair differentiation [J].
Chen, Jinhui ;
Hao, Zhaodong ;
Guang, Xuanmin ;
Zhao, Chenxi ;
Wang, Pengkai ;
Xue, Liangjiao ;
Zhu, Qihui ;
Yang, Linfeng ;
Sheng, Yu ;
Zhou, Yanwei ;
Xu, Haibin ;
Xie, Hongqing ;
Long, Xiaofei ;
Zhang, Jin ;
Wang, Zhangrong ;
Shi, Mingming ;
Lu, Ye ;
Liu, Siqin ;
Guan, Lanhua ;
Zhu, Qianhua ;
Yang, Liming ;
Ge, Song ;
Cheng, Tielong ;
Laux, Thomas ;
Gao, Qiang ;
Peng, Ye ;
Liu, Na ;
Yang, Sihai ;
Shi, Jisen .
NATURE PLANTS, 2019, 5 (01) :18-25
[6]   Capturing chromosome conformation [J].
Dekker, J ;
Rippe, K ;
Dekker, M ;
Kleckner, N .
SCIENCE, 2002, 295 (5558) :1306-1311
[7]   GenomeGraphs: integrated genomic data visualization with R [J].
Durinck, Steffen ;
Bullard, James ;
Spellman, Paul T. ;
Dudoit, Sandrine .
BMC BIOINFORMATICS, 2009, 10 :2
[8]   Real-Time DNA Sequencing from Single Polymerase Molecules [J].
Eid, John ;
Fehr, Adrian ;
Gray, Jeremy ;
Luong, Khai ;
Lyle, John ;
Otto, Geoff ;
Peluso, Paul ;
Rank, David ;
Baybayan, Primo ;
Bettman, Brad ;
Bibillo, Arkadiusz ;
Bjornson, Keith ;
Chaudhuri, Bidhan ;
Christians, Frederick ;
Cicero, Ronald ;
Clark, Sonya ;
Dalal, Ravindra ;
deWinter, Alex ;
Dixon, John ;
Foquet, Mathieu ;
Gaertner, Alfred ;
Hardenbol, Paul ;
Heiner, Cheryl ;
Hester, Kevin ;
Holden, David ;
Kearns, Gregory ;
Kong, Xiangxu ;
Kuse, Ronald ;
Lacroix, Yves ;
Lin, Steven ;
Lundquist, Paul ;
Ma, Congcong ;
Marks, Patrick ;
Maxham, Mark ;
Murphy, Devon ;
Park, Insil ;
Pham, Thang ;
Phillips, Michael ;
Roy, Joy ;
Sebra, Robert ;
Shen, Gene ;
Sorenson, Jon ;
Tomaney, Austin ;
Travers, Kevin ;
Trulson, Mark ;
Vieceli, John ;
Wegener, Jeffrey ;
Wu, Dawn ;
Yang, Alicia ;
Zaccarin, Denis .
SCIENCE, 2009, 323 (5910) :133-138
[9]   Epigenetic silencing of transposable elements: A trade-off between reduced transposition and deleterious effects on neighboring gene expression [J].
Hollister, Jesse D. ;
Gaut, Brandon S. .
GENOME RESEARCH, 2009, 19 (08) :1419-1428
[10]   The chromosome-scale reference genome of black pepper provides insight into piperine biosynthesis [J].
Hu, Lisong ;
Xu, Zhongping ;
Wang, Maojun ;
Fan, Rui ;
Yuan, Daojun ;
Wu, Baoduo ;
Wu, Huasong ;
Qin, Xiaowei ;
Yan, Lin ;
Tan, Lehe ;
Sim, Soonliang ;
Li, Wen ;
Saski, Christopher A. ;
Daniell, Henry ;
Wendel, Jonathan F. ;
Lindsey, Keith ;
Zhang, Xianlong ;
Hao, Chaoyun ;
Jin, Shuangxia .
NATURE COMMUNICATIONS, 2019, 10 (1)