Regulation of Formation of Monospecies and Binary Biofilms by Human Skin Microbiota Components, Staphylococcus epidermidis and Staphylococcus aureus, by Human Natriuretic Peptides

被引：17

作者：

Gannesen, A. V. ^{[1
,2
,3
]}

Lesouhaitier, O. ^{[3
]}

Netrusov, A. I. ^{[1
]}

Plakunov, V. K. ^{[2
]}

Feuilloley, M. G. J. ^{[3
]}

机构：

[1] Lomonosov Moscow State Univ, Moscow, Russia

[2] Russian Acad Sci, Res Ctr Biotechnol, Winogradsky Inst Microbiol, Moscow, Russia

[3] Univ Rouen, LMSM, EA4312, Evreux, France

来源：

MICROBIOLOGY | 2018年 / 87卷 / 05期

关键词：

natriuretic peptides; biofilms; binary biofilms; Staphylococcus aureus; Staphylococcus epidermidis; regulation of biofilm formation;

D O I：

10.1134/S0026261718050090

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human natriuretic peptides (NUPs) types A and C were shown have different effects on the growth of monospecies and binary biofilms of human skin commensal microorganisms Staphylococcus epidermidis and Staphylococcus aureus. The effect of natriuretic peptides depended on cultivation conditions: at 37 degrees C growth of monospecies biofilms formed by S. epidermidis and S. aureus was stimulated and inhibited, respectively, resulting in changed values of the biofilm average thickness and biomass in presence of NUPs. At 33 degrees C effects of NUPs reversed: growth of S. epidermidis monospecies biofilms was inhibited. In binary biofilms at 37 degrees C, NUPs were able to increase the competitiveness of S. epidermidis against S. aureus. NUPs affected predominantly biofilms and, to a lesser degree, planktonic cultures. This phenomenon makes it possible to consider NUPs as the molecules able to regulate the interactions between the human organism and skin microbiota.

引用

页码：597 / 609

页数：13

共 32 条

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