Experimental immobilization and remobilization rat knee joints: clinical and microscopic study

被引:10
|
作者
Del Carlo, R. J.
Galvao, M. R.
Viloria, M. I. V.
Natali, A. J.
Barbosa, A. L. T.
Monteiro, B. S.
Pinheiro, L. C. P.
机构
[1] Univ Fed Vicosa, Dept Vet, BR-36570 Vicosa, MG, Brazil
[2] Univ Fed Vicosa, Dept Educ Fis, Vicosa, MG, Brazil
关键词
rat; articular immobilization; articular remobilization; arthrosis;
D O I
10.1590/S0102-09352007000200015
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Thirty-four rats were randomly allocated into one of four experimental groups: without immobilization (G1), immobilization of the right knee joint for 45 days (G2), immobilization and remobilization with free activity for 5 weeks (G3), and immobilization and remobilization with free activity and swimming program for 5 weeks (G4). The immobilization was prejudicial to march and flexibility articular. Animals from G4 showed a better march evolution on the first five days as compared to those from G3. After that periods, march evolution were similar in both G3 and G4. Animals from G2 showed rigid joint while in those from G3 and G4 the articular movement was close to normal. The histological analysis pointed out that immobilization led to increase in articular capsule thickness evidenced by the presence of fibrous connective tissue replacing adipose tissue in G2, but proportionally less in G3 and G4. It was observed that immobilization determined loss of proteoglycans from the cartilaginous matrix, increase in the number of regularly arranged condrocytes, increase in calcified cartilage thickness, irregularity in the articular surface, proliferation of connective tissue in the intra-articular space and increase in
引用
收藏
页码:363 / 370
页数:8
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