Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold

被引：10

作者：

D'Errico, Stefano ^{[1
,2
]}

Borbone, Nicola ^{[1
,2
]}

Piccialli, Vincenzo ^{[3
]}

Di Gennaro, Elena ^{[4
]}

Zotti, Andrea ^{[4
]}

Budillon, Alfredo ^{[4
]}

Vitagliano, Carlo ^{[4
]}

Piccialli, Ilaria ^{[5
]}

Oliviero, Giorgia ^{[2
,6
]}

机构：

[1] Univ Napoli Federico II, Dipartimento Farm, Via Domenico Montesano 49, I-80131 Naples, Italy

[2] Univ Milano Bicocca, Ctr Syst Biol, SYSBIO IT, Milan, Italy

[3] Univ Napoli Federico II, Dipartimento Sci Chim, Via Cinthia 4, I-80126 Naples, Italy

[4] Fdn G Pascale IRCCS, Ist Nazl Tumori, Expt Pharmacol Unit, Via Mariano Semmola 52, I-80131 Naples, Italy

[5] Univ Napoli Federico II, Div Farmacol, Dipartimento Neurosci Sci Riprod & Odontostomatol, Scuola Med, Via Sergio Pansini 5, I-80131 Naples, Italy

[6] Univ Napoli Federico II, Dipartimento Med Mol & Biotecnol Med, Via Sergio Pansini 5, I-80131 Naples, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 33期

关键词：

Antitumor agents; Platinum; Nucleosides; Antiproliferative activity; SOLID-PHASE SYNTHESIS; PHARMACOLOGICAL EVALUATION; BIOLOGICAL EVALUATION; NATURAL-PRODUCTS; CANCER; DRUGS; ANALOGS; RIBOSE; DESIGN; NUCLEOSIDE;

D O I：

10.1002/ejoc.201700730

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report on the synthesis and evaluation of the preliminary antitumor properties of a small collection of platinum(II) complexes in which a cisplatin-like unit is tethered to 7-deazaadenosine through linear alkyl chains (from two to six carbon atoms) installed at the purine C6 position. The complexation was performed by exploiting the reactivity of the bi-dentate amino ligands (R)- and (S)-2,3-diaminopropanoic acids (DAPA) attached to the end of the alkyl chain spacer. By varying the length of the alkyl chain and the chirality of the DAPA moiety we obtained 10 novel nucleoside-platinum complexes, the anticancer properties of which have been evaluated against the A549 and Cal27 human cancer cell lines.

引用

页码：4935 / 4947

页数：13

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