The current treatment landscape: other fungal diseases (cryptococcosis, fusariosis and mucormycosis)

被引:11
作者
Lortholary, Olivier [1 ,2 ]
Fernandez-Ruiz, Mario [3 ]
Perfect, John R. [4 ,5 ]
机构
[1] Paris Descartes Univ, Necker Enfants Malades Univ Hosp, AP HP, Necker Pasteur Ctr Infect Dis & Trop Med,IHU Imag, Paris, France
[2] CNRS, Natl Reference Ctr Mycoses & Antifun, Mol Mycol Unit, Inst Pasteur,URA 3012, Paris, France
[3] Univ Complutense, Hosp Univ Octubre 12, Unit Infect Dis, Inst Invest,Hosp Octubre 12 I 12, Madrid, Spain
[4] Duke Univ, Med Ctr, Div Infect Dis, Durham, NC USA
[5] Duke Univ, Med Ctr, Dept Med, Durham, NC USA
关键词
LIPOSOMAL AMPHOTERICIN-B; HIV-INFECTED PERSONS; STEM-CELL TRANSPLANT; INVASIVE FUSARIOSIS; ANTIRETROVIRAL THERAPY; BREAKTHROUGH FUSARIUM; COST-EFFECTIVENESS; MOLD INFECTIONS; MENINGITIS; ANTIGENEMIA;
D O I
10.1093/jac/dkw394
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Compared with major invasive mycoses such as aspergillosis and candidiasis, the antifungal stewardship management strategies of other fungal diseases have different opportunities and considerations. Cryptococcosis, fusariosis and mucormycosis are globally prevalent invasive fungal diseases (IFDs), but are not currently included in antifungal prophylaxis guidelines for immunocompromised hosts. Since the implementation of biomarkers as part of diagnostic screening strategies, the concept of pre-emptive antifungal therapy has emerged for these IFDs. Management of cryptococcosis, the most common IFD worldwide, generally utilizes a pre-emptive or therapeutic strategy that does not involve prophylaxis or empirical antifungal treatment strategies. Antifungal stewardship outcomes for cryptococcosis may vary according to the availability of local resources. Invasive fusariosis, the second-most common form of non-Aspergillus mould infection among haematological malignancy patients, can be managed with pre-emptive (or diagnostic-driven) approaches based on the monitoring of serum galactomannan (GM) antigen in increased-risk populations. The success of antimicrobial stewardship programmes in decreasing the burden of invasive fusariosis in selected patient populations depends on the development and implementation of rapid diagnostic strategies for early and appropriate administration of therapy. Mucormycosis may emerge as a breakthrough IFD in haematology or solid organ transplant recipients receiving antifungals that lack activity against Mucorales. The concept of pre-emptive antifungal therapy has thus arisen for mucormycosis in the haematology setting because of the recent availability of circulating Mucorales DNA measurement. These examples demonstrate the challenges of implementing antifungal stewardship programmes in areas with limited resources, as well as in IFDs that are difficult to diagnose and treat.
引用
收藏
页码:31 / 36
页数:6
相关论文
共 63 条
[1]   In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents [J].
Almyroudis, Nikolaos G. ;
Sutton, Deanna A. ;
Fothergill, Annette W. ;
Rinaldi, Michael G. ;
Kusne, Shimon .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (07) :2587-2590
[2]   Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options [J].
Ashley, Elizabeth Dodds ;
Drew, Richard ;
Johnson, Melissa ;
Danna, Robert ;
Dabrowski, Dominika ;
Walker, Valery ;
Prasad, Manishi ;
Alexander, Barbara ;
Papadopoulos, George ;
Perfect, John .
PHARMACOTHERAPY, 2012, 32 (10) :890-901
[3]   Population-Based Analysis of Invasive Fungal Infections, France, 2001-2010 [J].
Bitar, Dounia ;
Lortholary, Olivier ;
Le Strat, Yann ;
Nicolau, Javier ;
Coignard, Bruno ;
Tattevin, Pierre ;
Che, Didier ;
Dromer, Francoise .
EMERGING INFECTIOUS DISEASES, 2014, 20 (07) :1149-1155
[4]   Disseminated Fusariosis Occurring in Two Patients Despite Posaconazole Prophylaxis [J].
Bose, Prithviraj ;
Parekh, Hiral D. ;
Holter, Jennifer L. ;
Greenfield, Ronald A. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (04) :1674-1675
[5]   Approaches to Antifungal Therapies and Their Effectiveness among Patients with Cryptococcosis [J].
Bratton, Emily W. ;
El Husseini, Nada ;
Chastain, Cody A. ;
Lee, Michael S. ;
Poole, Charles ;
Stuermer, Til ;
Weber, David J. ;
Juliano, Jonathan J. ;
Perfect, John R. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (06) :2485-2495
[6]   Invasive fusariosis in patients with hematologic malignancies at a cancer center: 1998-2009 [J].
Campo, Marcela ;
Lewis, Russell E. ;
Kontoyiannis, Dimitrios P. .
JOURNAL OF INFECTION, 2010, 60 (05) :331-337
[7]   Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients [J].
Chan, Thomas S. Y. ;
Gill, Harinder ;
Hwang, Yu-Yan ;
Sim, Joycelyn ;
Tse, Alan C. T. ;
Loong, Florence ;
Khong, Pek-Lan ;
Tse, Eric ;
Leung, Anskar Y. H. ;
Chim, Chor-Sang ;
Lie, Albert K. W. ;
Kwong, Yok-Lam .
ANNALS OF HEMATOLOGY, 2014, 93 (03) :493-498
[8]   ESCMID† and ECMM‡ joint clinical guidelines for the diagnosis and management of mucormycosis 2013 [J].
Cornely, O. A. ;
Arikan-Akdagli, S. ;
Dannaoui, E. ;
Groll, A. H. ;
Lagrou, K. ;
Chakrabarti, A. ;
Lanternier, F. ;
Pagano, L. ;
Skiada, A. ;
Akova, M. ;
Arendrup, M. C. ;
Boekhout, T. ;
Chowdhary, A. ;
Cuenca-Estrella, M. ;
Freiberger, T. ;
Guinea, J. ;
Guarro, J. ;
de Hoog, S. ;
Hope, W. ;
Johnson, E. ;
Kathuria, S. ;
Lackner, M. ;
Lass-Floerl, C. ;
Lortholary, O. ;
Meis, J. F. ;
Meletiadis, J. ;
Munoz, P. ;
Richardson, M. ;
Roilides, E. ;
Tortorano, A. M. ;
Ullmann, A. J. ;
van Diepeningen, A. ;
Verweij, P. ;
Petrikkos, G. .
CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 :5-26
[9]   Breakthrough fusariosis in a patient with acute lymphoblastic leukemia receiving voriconazole prophylaxis [J].
Cudillo, L ;
Girmenia, C ;
Santilli, S ;
Picardi, A ;
Dentamaro, T ;
Tendas, A ;
de Fabritiis, P .
CLINICAL INFECTIOUS DISEASES, 2005, 40 (08) :1212-1213
[10]   Healthcare-associated outbreaks due to Mucorales and other uncommon fungi [J].
Davoudi, Setareh ;
Graviss, Linda S. ;
Kontoyiannis, Dimitrios P. .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2015, 45 (07) :767-773