Highly Regioselective Arylation of 1,2,3-Triazole N-Oxides with Sodium Arenesulfinates via Palladium-Catalyzed Desulfitative Cross-Coupling Reaction

被引：13

作者：

Zhu, Jiayi ^{[1
]}

Chen, Yu ^{[1
]}

Lin, Feng ^{[1
]}

Wang, Baoshuang ^{[1
]}

Huang, Qing ^{[1
]}

Liu, Liangxian ^{[1
]}

机构：

[1] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Jiangxi, Peoples R China

来源：

SYNLETT | 2015年 / 26卷 / 08期

关键词：

palladium; 1; 2; 3-triazole N-oxide; arylation; sodium arylsulfinate; C-H ARYLATION; ARYL SULFINIC ACIDS; BOND FORMATION; ARYLBORONIC ACIDS; PHOSPHINE OXIDES; CLICK CHEMISTRY; HETEROARENES; INDOLES; SALTS; (HETERO)ARENES;

D O I：

10.1055/s-0034-1380186

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and highly regioselective palladium-catalyzed direct C5-arylation of 1,2,3-triazole N-oxides was developed in the presence of silver carbonate and tripotassium phosphate. This protocol allowed use of sodium arylsulfinates, diphenylphosphine oxide, and triphenylphosphine as arylating reagents to produce 2-aryl-5-aryl-1,2,3-triazole N-oxides in good to excellent yields, providing a complement to the existing methods for the direct arylation of 1,2,3-triazole N-oxides.

引用

页码：1124 / 1130

页数：7

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