The Roles of Dopamine Oxidative Stress and Dopamine Receptor Signaling in Aging and Age-Related Neurodegeneration

被引：68

作者：

Luo, Yongquan ^{[1
]}

Roth, George S. ^{[1
]}

机构：

[1] NIA, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1089/15230860050192224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is accompanied by a decline of functions controlled by the central dopaminergic system, such as reduced locomotor activity, motivation, impairment of memory formation, and learning deficits. The molecular mechanisms underlying age-related impairment of dopaminergic functions are unknown. Current literature and our own recent work, which are reviewed and summarized in the present paper, suggest that dopamine oxidative stress and its subsequent signaling may contribute to the aging of dopaminergic system. Antiox. Redox Signal. 2, 449-460.

引用

收藏

页码：449 / 460

页数：12

相关论文

共 88 条

[41] IRON MELANIN COMPLEX IN SUBSTANTIA-NIGRA OF PARKINSONIAN BRAINS - AN X-RAY-MICROANALYSIS [J].

JELLINGER, K ;

KIENZL, E ;

RUMPELMAIR, G ;

RIEDERER, P ;

STACHELBERGER, H ;

BENSHACHAR, D ;

YOUDIM, MBH .

JOURNAL OF NEUROCHEMISTRY, 1992, 59 (03) :1168-1171

[42]

JENNER P, 1993, ACTA NEUROL SCAND S, V146, P6

[43] THE STRESS-ACTIVATED PROTEIN-KINASE SUBFAMILY OF C-JUN KINASES [J].

KYRIAKIS, JM ;

BANERJEE, P ;

NIKOLAKAKI, E ;

DAI, TA ;

RUBIE, EA ;

AHMAD, MF ;

AVRUCH, J ;

WOODGETT, JR .

NATURE, 1994, 369 (6476) :156-160

[44] CULTURED RAT STRIATAL AND CORTICAL ASTROCYTES PROTECT MESENCEPHALIC DOPAMINERGIC-NEURONS AGAINST HYDROGEN-PEROXIDE TOXICITY INDEPENDENT OF THEIR EFFECT ON NEURONAL DEVELOPMENT [J].

LANGEVELD, CH ;

JONGENELEN, CAM ;

SCHEPENS, E ;

STOOF, JC ;

BAST, A ;

DRUKARCH, B .

NEUROSCIENCE LETTERS, 1995, 192 (01) :13-16

[45] A PROTEIN-KINASE INVOLVED IN THE REGULATION OF INFLAMMATORY CYTOKINE BIOSYNTHESIS [J].

LEE, JC ;

LAYDON, JT ;

MCDONNELL, PC ;

GALLAGHER, TF ;

KUMAR, S ;

GREEN, D ;

MCNULTY, D ;

BLUMENTHAL, MJ ;

HEYS, JR ;

LANDVATTER, SW ;

STRICKLER, JE ;

MCLAUGHLIN, MM ;

SIEMENS, IR ;

FISHER, SM ;

LIVI, GP ;

WHITE, JR ;

ADAMS, JL ;

YOUNG, PR .

NATURE, 1994, 372 (6508) :739-746

[46] Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats? [J].

Levin, ED ;

Torry, D ;

Christopher, NC ;

Yu, X ;

Einstein, G ;

SchwartzBloom, RD .

BRAIN RESEARCH BULLETIN, 1997, 43 (03) :295-304

[47] INHIBITION OF NUCLEAR TRANSLOCATION OF TRANSCRIPTION FACTOR NF-KAPPA-B BY A SYNTHETIC PEPTIDE-CONTAINING A CELL MEMBRANE-PERMEABLE MOTIF AND NUCLEAR-LOCALIZATION SEQUENCE [J].

LIN, YZ ;

YAO, SY ;

VEACH, RA ;

TORGERSON, TR ;

HAWIGER, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (24) :14255-14258

[48] Reactive oxygen species mediate cytokine activation of c-jun NH2-terminal kinases [J].

Lo, YYC ;

Wong, JMS ;

Cruz, TF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (26) :15703-15707

[49] SPATIAL MEMORY DEFICITS IN AGED RATS - CONTRIBUTIONS OF MONOAMINERGIC SYSTEMS [J].

LUINE, V ;

BOWLING, D ;

HEARNS, M .

BRAIN RESEARCH, 1990, 537 (1-2) :271-278

[50] Intrastriatal dopamine injection induces apoptosis through oxidation-involved activation of transcription factors AP-1 and NF-κB in rats [J].

Luo, YQ ;

Hattori, A ;

Munoz, J ;

Qin, ZH ;

Roth, GS .

MOLECULAR PHARMACOLOGY, 1999, 56 (02) :254-264

← 1 2 3 4 5 6 7 8 9 →