The Roles of Dopamine Oxidative Stress and Dopamine Receptor Signaling in Aging and Age-Related Neurodegeneration

被引：68
作者：
Luo, Yongquan [1 ]
Roth, George S. [1 ]
机构：
[1] NIA, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA
来源：
ANTIOXIDANTS & REDOX SIGNALING | 2000年 / 2卷 / 03期
关键词：
D O I：
10.1089/15230860050192224
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is accompanied by a decline of functions controlled by the central dopaminergic system, such as reduced locomotor activity, motivation, impairment of memory formation, and learning deficits. The molecular mechanisms underlying age-related impairment of dopaminergic functions are unknown. Current literature and our own recent work, which are reviewed and summarized in the present paper, suggest that dopamine oxidative stress and its subsequent signaling may contribute to the aging of dopaminergic system. Antiox. Redox Signal. 2, 449-460.
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页码：449 / 460
页数：12
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