The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis

被引：71

作者：

Brownlee, Peter M. ^{[1
]}

Meisenberg, Cornelia ^{[1
]}

Downs, Jessica A. ^{[1
]}

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

来源：

DNA REPAIR | 2015年 / 32卷

基金：

英国医学研究理事会;

关键词：

SWI/SNF; PBAF; BRG1; BAF180; Chromatin remodelling complex; Tumourigenesis; Genome instability; DNA damage induced transcriptional repression; Cohesion; DOUBLE-STRAND BREAKS; CHROMOSOME COHESION; BLADDER-CANCER; DNA-DAMAGE; HOMOLOGOUS RECOMBINATION; INSTABILITY; REPAIR; TRANSCRIPTION; HETEROCHROMATIN; RECRUITMENT;

D O I：

10.1016/j.dnarep.2015.04.023

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genes encoding subunits of the two SWI/SNF chromatin remodelling complexes (BAF and PBAF) are mutated in almost 20% of all human cancers. In addition to a role in regulating transcription, recent work from our laboratory and others identified roles for both complexes in DNA damage responses and the maintenance of sister chromatid cohesion, which may have profound impacts on genome stability and contribute to its role as a tumour suppressor. Here, we review some of the transcription-independent functions of the SWI/SNF chromatin remodelling complex and discuss these in light of their potential relevance to tumourigenesis. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：127 / 133

页数：7

共 63 条

[1] R Loops: From Transcription Byproducts to Threats to Genome Stability [J].

Aguilera, Andres ;

Garcia-Muse, Tatiana .

MOLECULAR CELL, 2012, 46 (02) :115-124

[2] Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks [J].

Aymard, Francois ;

Bugler, Beatrix ;

Schmidt, Christine K. ;

Guillou, Emmanuelle ;

Caron, Pierre ;

Briois, Sebastien ;

Iacovoni, Jason S. ;

Daburon, Virginie ;

Miller, Kyle M. ;

Jackson, Stephen P. ;

Legube, Gaelle .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (04) :366-U172

[3] Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy [J].

Balbas-Martinez, Cristina ;

Sagrera, Ana ;

Carrillo-de-Santa-Pau, Enrique ;

Earl, Julie ;

Marquez, Mirari ;

Vazquez, Miguel ;

Lapi, Eleonora ;

Castro-Giner, Francesc ;

Beltran, Sergi ;

Bayes, Monica ;

Carrato, Alfredo ;

Cigudosa, Juan C. ;

Dominguez, Orlando ;

Gut, Marta ;

Herranz, Jesus ;

Juanpere, Nuria ;

Kogevinas, Manolis ;

Langa, Xavier ;

Lopez-Knowles, Elena ;

Lorente, Jose A. ;

Lloreta, Josep ;

Pisano, David G. ;

Richart, Laia ;

Rico, Daniel ;

Salgado, Rocio N. ;

Tardon, Adonina ;

Chanock, Stephen ;

Heath, Simon ;

Valencia, Alfonso ;

Losada, Ana ;

Gut, Ivo ;

Malats, Nuria ;

Real, Francisco X. .

NATURE GENETICS, 2013, 45 (12) :1464-U221

[4] BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer [J].

Bochar, DA ;

Wang, L ;

Beniya, H ;

Kinev, A ;

Xue, YT ;

Lane, WS ;

Wang, WD ;

Kashanchi, F ;

Shiekhattar, R .

CELL, 2000, 102 (02) :257-265

[5] SWI/SNF Deficiency Results in Aberrant Chromatin Organization, Mitotic Failure, and Diminished Proliferative Capacity [J].

Bourgo, Ryan J. ;

Siddiqui, Hasan ;

Fox, Sejal ;

Solomon, David ;

Sansam, Courtney G. ;

Yaniv, Moshe ;

Muchardt, Christian ;

Metzger, Daniel ;

Chambon, Pierre ;

Roberts, Charles W. M. ;

Knudsen, Erik S. .

MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (14) :3192-3199

[6] APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer [J].

Brough, Rachel ;

Bajrami, Ilirjana ;

Vatcheva, Radost ;

Natrajan, Rachael ;

Reis-Filho, Jorge S. ;

Lord, Christopher J. ;

Ashworth, Alan .

EMBO JOURNAL, 2012, 31 (05) :1160-1176

[7] BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy [J].

Brownlee, Peter M. ;

Chambers, Anna L. ;

Cloney, Ross ;

Bianchi, Alessandro ;

Downs, Jessica A. .

CELL REPORTS, 2014, 6 (06) :973-981

[8] Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells [J].

Canudas, Silvia ;

Smith, Susan .

JOURNAL OF CELL BIOLOGY, 2009, 187 (02) :165-173

[9] Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres [J].

Carretero, Maria ;

Ruiz-Torres, Miguel ;

Rodriguez-Corsino, Miriam ;

Barthelemy, Isabel ;

Losada, Ana .

EMBO JOURNAL, 2013, 32 (22) :2938-2949

[10] The RSC and INO80 Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair [J].

Chambers, Anna L. ;

Downs, Jessica A. .

MECHANISMS OF DNA REPAIR, 2012, 110 :229-261

← 1 2 3 4 5 6 7 →