The Preventive Effect of IL-1beta Antagonist on Diabetic Peripheral Neuropathy

被引：17
作者：
Zheng Hangping [1 ]
Han Ling [3 ,4 ]
Ji Lijin [1 ]
Zhao Wenting [1 ,5 ]
Liu Xiaoxia [1 ]
Zhang Qi [1 ]
Zhu Xiaoming [1 ]
Li Qingchun [1 ]
Li Yiming [1 ]
Xiong Qian [1 ,2 ]
Hu Ji [3 ]
Lu Bin [1 ]
Zhang Shuo [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Endocrinol & Metab, 12 Middle Wulumuqi Rd, Shanghai, Peoples R China
[2] Gonghui Hosp, Dept Endocrinol & Metab, 6 315 Lane,First Shimen Rd, Shanghai, Peoples R China
[3] Soochow Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, 1055 Sanxiang Rd, Suzhou, Jiangsu, Peoples R China
[4] Hlth Serv Ctr, Jiubao St, Hangzhou, Zhejiang, Peoples R China
[5] Qinghai Univ, Dept Endocrinol & Metab, Affiliated Hosp, 29 Tongren Rd, Xining, Qinghai, Peoples R China
来源：
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS | 2020年 / 20卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Diabetic peripheral neuropathy; IL-1beta; IL-1RA; inflammation; prevention; rats; INSULIN-RESISTANCE; NERVE; PAIN; INTERLEUKIN-1-BETA; EPIDEMIOLOGY; PROGRESSION; MODEL;
D O I：
10.2174/1871530319666191022114139
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To investigate the relationship between Interleukin-1beta (IL-1beta) and diabetic peripheral neuropathy (DPN) using animal models. Methods: The rat model of diabetic neuropathy was induced by intraperitoneal injection of a single dose of streptozotocin (STZ) at 65mg/kg. Diabetic rats were randomly divided into two groups (10 each), one treated with 0.9% saline (DMS group) and the other with interleukin-1 receptor antagonist (IL-1RA) at 50mg/kg (DMI group) twice a day for 5 weeks. Ten normal rats matched for weight, age and sex served as normal controls (Con group) and were treated with saline. Morphologic studies of sciatic nerves were achieved using light and transmission electron microscopy. Results: Transmission electron microscopy of the sciatic nerve showed the ultrastructure of myelin and the axon in the IL-1RA group was highly protected compared to diabetic controls. Conclusion: High levels of circulating IL-1beta may be associated with the risk of DPN and anti-IL-1 treatment may provide a potential strategy for the prevention of diabetic neuropathy.
引用
收藏
页码：753 / 759
页数：7
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