N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

被引：6
作者：
Cuccu, Federico [1 ]
Basoccu, Francesco [1 ]
Fattuoni, Claudia [1 ]
Porcheddu, Andrea [1 ]
机构：
[1] Univ Cagliari, Dept Chem & Geol Sci, I-09124 Monserrato, Italy
来源：
MOLECULES | 2022年 / 27卷 / 17期
关键词：
formamides; green chemistry; ball milling; mechanochemistry; saccharin; SECONDARY-AMINES; AMIDES; ACID; DERIVATIVES; SOLVENT; REARRANGEMENT; ISOCYANIDES; FORMAMIDES; ISONITRILE; CATALYST;
D O I：
10.3390/molecules27175450
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin, and N-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
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页数：11
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