An efficient method to convert lactams and amides into 2,2-dialkylated amines

被引：39

作者：

Agosti, Alessandro ^{[1
]}

Britto, Sebastian ^{[1
]}

Renaud, Philippe ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 07期

关键词：

D O I：

10.1021/ol800145h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical method for the synthesis of gern-2,2-disubstituted tertiary amines from the corresponding lactams (or amides) is reported. It is based on the reaction of thioiminium ions, easily prepared from lactams and amides with organometallic reagents such allylmagnesium, benzyl magnesium, and primary alkylcerium reagents.

引用

页码：1417 / 1420

页数：4

共 20 条

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