Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway

被引：20

作者：

Bommareddy, Ajay ^{[1
]}

Knapp, Kacey ^{[1
]}

Nemeth, Abigail ^{[1
]}

Steigerwalt, James ^{[1
]}

Landis, Terra ^{[1
]}

Vanwert, Adam L. ^{[1
]}

Gorijavolu, Harsha P. ^{[2
]}

Dwivedi, Chandradhar ^{[3
]}

机构：

[1] Wilkes Univ, Dept Pharmaceut Sci, Nesbitt Sch Pharm, 84 W South St, Wilkes Barre, PA 18766 USA

[2] Aurobindo Pharma, Dayton, NJ USA

[3] South Dakota State Univ, Coll Pharm, Dept Pharmaceut Sci, Brookings, SD USA

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 08期

关键词：

Alpha-santalol; beta-catenin; breast cancer; SURVIVIN; SKIN;

D O I：

10.21873/anticanres.12750

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that alpha-santalol treatment targets Wnt/beta-catenin pathway to inhibit migration of cultured breast cancer cells. Materials and Methods: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of alpha-santalol in breast cancer cells. Results: Exposure of MDA-MB 231 and MCF-7 cells to alpha-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, alpha-santalol affected the localization of beta-catenin from cytosol to nucleus in MDA-MB 231 cells. Conclusion: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wndlfl-catenin pathway. beta-catenin represents an important target of alpha-santalol's response for future preclinical studies.

引用

页码：4475 / 4480

页数：6

共 18 条

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