Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

被引：203

作者：

Feau, Sonia ^{[1
]}

Arens, Ramon ^{[1
]}

Togher, Susan ^{[1
]}

Schoenberger, Stephen P. ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Cellular Immunol Lab, La Jolla, CA USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 09期

基金：

美国国家卫生研究院;

关键词：

INTERLEUKIN-2 DEFICIENT MICE; DENDRITIC CELL; CD8-T-CELL MEMORY; CD4-T-CELL HELP; SELF-ANTIGENS; IN-VIVO; RESPONSES; MOUSE; LYMPHOCYTES; ACTIVATION;

D O I：

10.1038/ni.2079

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two competing theories have been put forward to explain the role of CD4(+) T cells in priming CD8(+) memory T cells: one proposes paracrine secretion of interleukin 2 (IL-2); the other proposes the activation of antigen-presenting cells (APCs) via the costimulatory molecule CD40 and its ligand CD40L. We investigated the requirement for IL-2 by the relevant three cell types in vivo and found that CD8(+) T cells, rather than CD4(+) T cells or dendritic cells (DCs), produced the IL-2 necessary for CD8(+) T cell memory. Il2(-/-) CD4(+) T cells were able to provide help only if their ability to transmit signals via CD40L was intact. Our findings reconcile contradictory elements implicit in each model noted above by showing that CD4(+) T cells activate APCs through a CD40L-dependent mechanism to enable autocrine production of IL-2 in CD8(+) memory T cells.

引用

页码：908 / U132

页数：7

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