The Potential of the CNS as a Reservoir for HIV-1 Infection: Implications for HIV Eradication

被引：46

作者：

Fois, Alessandro F. ^{[1
]}

Brew, Bruce J. ^{[1
,2
]}

机构：

[1] St Vincents Hosp, Dept Neurol, Darlinghurst, NSW 2010, Australia

[2] St Vincents Hosp, Peter Duncan Neurosci Unit, St Vincents Ctr Appl Med Res, Sydney, NSW 2010, Australia

来源：

CURRENT HIV/AIDS REPORTS | 2015年 / 12卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Brain; Central nervous system; Eradication; Latency; HIV; Reservoir; ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; VIRAL RESERVOIRS; SUPPRESSIVE THERAPY; SITU HYBRIDIZATION; IMMUNE ACTIVATION; ESCAPE MUTATIONS; PLASMA VIREMIA;

D O I：

10.1007/s11904-015-0257-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The ability of HIV-1 to establish latent infection is a key obstacle to its eradication despite the existence of effective antiretroviral drugs. The brain has been postulated as a reservoir for latent infection, but its role in HIV persistence remains unclear. In this review, we discuss the evidence surrounding the role of the central nervous system (CNS) as a viral reservoir and the potential challenges this might present in eradicating HIV. The strategies for eradication of HIV and their application to latent CNS infection are explored. Finally, we outline new developments in drug delivery and new therapeutic modalities designed to target HIV infection in the CNS.

引用

页码：299 / 303

页数：5

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