Understanding the Cross-Talk between Ovarian Tumors and Immune Cells: Mechanisms for Effective Immunotherapies

被引：8

作者：

Chiriva-Internati, Maurizio ^{[1
,2
,3
,4
]}

Mirandola, Leonardo ^{[1
,2
,3
,4
]}

Kast, W. Martin ^{[5
,6
,7
,8
]}

Jenkins, Marjorie R. ^{[1
,2
,3
,4
]}

Cobos, Everardo ^{[1
,2
,3
,4
]}

Cannon, Martin J. ^{[9
]}

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Div Hematol Oncol, Dept Internal Med, Lubbock, TX 79430 USA

[2] SW Canc Treatment & Res Ctr, Lubbock, TX USA

[3] Texas Tech Univ, Hlth Sci Ctr, Laura W Bush Inst Womens Hlth, Amarillo, TX USA

[4] Texas Tech Univ, Hlth Sci Ctr, Ctr Womens Hlth, Amarillo, TX USA

[5] Univ So Calif, Dept Mol Microbiol, Los Angeles, CA USA

[6] Univ So Calif, Dept Immunol, Los Angeles, CA USA

[7] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA USA

[8] Univ Hawaii Manoa, Canc Res Ctr Hawaii, Honolulu, HI 96822 USA

[9] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2011年 / 30卷 / 2-3期

关键词：

ovarian cancer; dendritic cells; T-reg; recombinant adeno-associated virus; T cells; adoptive immunotherapies; CYTOTOXIC T-LYMPHOCYTES; HUMAN DENDRITIC CELLS; RECOMBINANT ADENOASSOCIATED VIRUS; INVARIANT NKT CELLS; EPITHELIAL OVARIAN; INDOLEAMINE 2,3-DIOXYGENASE; PROGNOSTIC-FACTOR; CANCER-PATIENTS; MESSENGER-RNA; IN-VITRO;

D O I：

10.3109/08830185.2011.561507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite decades of research, ovarian cancer remains a lethal disease. Recent studies have reported the critical role played by the immune system in controlling growth and spread of ovarian tumors. Accordingly, immunotherapy has been indicated as the most likely successful new approach in the treatment of the disease. Unfortunately, ovarian cancer triggers immune inhibitory mechanisms that hamper anti-tumor responses. Therefore, future immunotherapies should be able to overcome these obstacles. Here we review the basic mechanisms of tumor immune surveillance with a particular focus on ovarian cancer, and we discuss cutting-edge strategies to promote immune system eradication of ovarian tumors.

引用

页码：71 / 86

页数：16

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