Effects of Acute Hepatic and Renal Failure on Pharmacokinetics of Flunixin Meglumine in Rats

被引：9
作者：
Hwang, Youn-Hwan [2 ]
Yun, Hyo-In [1 ,2 ]
机构：
[1] Chungnam Natl Univ, Coll Vet Med, Dept Vet Pharmacol & Toxicol, Taejon 305764, South Korea
[2] Chungnam Natl Univ, Inst Vet Sci, Taejon 305764, South Korea
来源：
EXPERIMENTAL ANIMALS | 2011年 / 60卷 / 02期
关键词：
acute renal and hepatic failure; flunixin; pharmacokinetics; ACTIVE-TRANSPORT MECHANISM; CARBON-TETRACHLORIDE; HORSES; LIVER; PHENYLBUTAZONE; ENROFLOXACIN; DISPOSITION; CAT; ENDOTOXEMIA; HEALTHY;
D O I：
10.1538/expanim.60.187
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The aim of this study was to investigate the effects of hepatic and renal failure on the pharmacokinetics of flunixin in carbon tetrachloride (CCl(4))- and glycerol-treated rats. After intravenous administration of flunixin (2 mg/kg), the plasma concentration of flunixin was measured by high-performance liquid chromatography. Both acute hepatic and renal failure resulted in significantly increased area under the curve (AUC), prolonged elimination half-life (t(1/2 beta)), and reduced total body clearance (Cl(tot)) compared with respective controls (P < 0.05). In conclusion, hepatic failure as well as renal failure modified the pharmacokinetics of flunixin.
引用
收藏
页码：187 / 191
页数：5
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