APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese

被引：32

作者：

Chien, Kuo-Liong ^{[2
]}

Fang, Woei-Horng ^{[1
]}

Wen, Hui-Chin ^{[1
]}

Lin, Hsing-Pei ^{[1
]}

Lin, Yen-Lin ^{[1
]}

Lin, Shu-Wha ^{[1
]}

Wu, June-Hsieh

Kao, Jau-Tsuen ^{[1
,3
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Dept Clin Lab Sci & Med Biotechnol, Taipei, Taiwan

[2] Natl Taiwan Univ, Coll Publ Sch, Inst Prevent Med, Taipei, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 100, Taiwan

来源：

CLINICA CHIMICA ACTA | 2008年 / 390卷 / 1-2期

关键词：

apolipoprotein A1/C3/A5; triglyceride; HDL cholesterol; haplotype;

D O I：

10.1016/j.cca.2007.12.014

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations. We investigated 2 distinct APOA1/C3/A5 haplotypes roles for hypertriglyceridemia. Methods: We recruited 308 cases of hypertriglyceridemia and 281 normal controls from a hospital. Twelve single nucleotide polymorphisms (SNPs) across the APOA1/C3/A5 gene region were genotyped. Results: One haplotype containing the minor alleles of the APOA5 (-1131T>C, c.553G>T) and APOA1 (-3013C>T,-75G>A) was more prevalent in cases than in controls (11.3% vs. 1.1%, respectively) and was statistically significantly associated with high triglycerides (adjusted odds ratio: 12.83, 95% confidence interval [CI]: 5.1-32.4, P<0.001). Another haplotype that was associated with hypertriglyceridemia (adjusted odds ratio 2.13, 95% CI, 1.37-3.29, P=0.001). Participants carrying both minor alleles of APOA5-1131CC and c.553TT had a 116% higher triglyceride concentration compared with those carrying common allele. Conclusions: The APOA1/C3/A5 haplotype represents an important locus for predicting risk of hypertriglyceridemia among Taiwanese. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：56 / 62

页数：7

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