Antituberculous activity of norfloxacin Mannich bases with isatin derivatives

被引：50

作者：

Pandeya, SN ^{[1
]}

Sriram, D

Yogeeswari, P

Ananthan, S

机构：

[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

[2] So Res Inst, TAACF, NIAID, Birmingham, AL 35255 USA

来源：

CHEMOTHERAPY | 2001年 / 47卷 / 04期

关键词：

isatin; norfloxacin; Mannich bases; antituberculous;

D O I：

10.1159/000048533

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

pounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 12.5 mug/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The lower than 6.25 mug/ml.

引用

页码：266 / 269

页数：4

共 9 条

[1] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
Collins, LA
Franzblau, SG
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) : 1004 - 1009
[2] Inderlied C. B., 1996, Antibiotics in laboratory medicine, P127
[3] Inderlied Clark B., 1995, P1385
[4] STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANTI-BACTERIAL 6,7-DISUBSTITUTED AND 7,8-DISUBSTITUTED 1-ALKYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS
KOGA, H
ITOH, A
MURAYAMA, S
SUZUE, S
IRIKURA, T
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) : 1358 - 1363
[5] Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives
Pandeya, SN
Yogeeswari, P
Sriram, D
de Clercq, E
Pannecouque, C
Witvrouw, M
[J]. CHEMOTHERAPY, 1999, 45 (03) : 192 - 196
[6] Pandeya SN, 1998, ACTA PHARM TURC, V40, P33
[7] POPP DF, 1975, ADV HETEROCYCLIC CHE, V18
[8] Surendra, 1998, Boll Chim Farm, V137, P321
[9] WOLFF ME, 1995, BURGERS MED CHEM DRU, V2, P575

← 1 →