Antituberculous activity of norfloxacin Mannich bases with isatin derivatives

被引：50

作者：

Pandeya, SN ^{[1
]}

Sriram, D

Yogeeswari, P

Ananthan, S

机构：

[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

[2] So Res Inst, TAACF, NIAID, Birmingham, AL 35255 USA

来源：

CHEMOTHERAPY | 2001年 / 47卷 / 04期

关键词：

isatin; norfloxacin; Mannich bases; antituberculous;

D O I：

10.1159/000048533

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

pounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 12.5 mug/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The lower than 6.25 mug/ml.

引用

页码：266 / 269

页数：4

共 9 条

[1] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[2]

Inderlied C. B., 1996, Antibiotics in laboratory medicine, P127

[3]

Inderlied Clark B., 1995, P1385

[4] STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANTI-BACTERIAL 6,7-DISUBSTITUTED AND 7,8-DISUBSTITUTED 1-ALKYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS [J].

KOGA, H ;

ITOH, A ;

MURAYAMA, S ;

SUZUE, S ;

IRIKURA, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (12) :1358-1363

[5] Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives [J].

Pandeya, SN ;

Yogeeswari, P ;

Sriram, D ;

de Clercq, E ;

Pannecouque, C ;

Witvrouw, M .

CHEMOTHERAPY, 1999, 45 (03) :192-196

[6]

Pandeya SN, 1998, ACTA PHARM TURC, V40, P33

[7]

POPP DF, 1975, ADV HETEROCYCLIC CHE, V18

[8]

Surendra, 1998, Boll Chim Farm, V137, P321

[9]

WOLFF ME, 1995, BURGERS MED CHEM DRU, V2, P575

← 1 →