Synthesis, Crystal Structure and DNA-Binding Studies of an Oxovanadium(IV) Complex [VO(Naph-Phe)(Phen)] with Mixed-Ligands

被引：0

作者：

Bian Lin ^{[1
]}

Li Lian-Zhi ^{[1
]}

Wang Xia ^{[1
]}

Huang Lei ^{[1
]}

Pu Xue-Wei ^{[1
]}

Dong Jian-Fang ^{[1
]}

机构：

[1] Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2011年 / 27卷 / 04期

关键词：

vanadium complex; Schiff base; crystal structure; DNA; BASE COMPLEXES; CLEAVAGE; PHENANTHROLINE; FLUORESCENCE; VANADIUM; GLUCOSE;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new oxovanadium complex with mixed-ligands of a Schiff base (Naph-Phe) derived from L-phenylalanine and 2-hydroxy-1-naphthaldehyde and 1,10-phenanthroline (Phen), [VO(Naph-.Phe)(Phen)], has been synthesized and characterized by elementary analysis, IR and single crystal X-ray diffraction. It was shown that the complex crystallized in monoclinic crystal system, P2(1/c) space group with the cell parameters: a=1.027 85(11) nm, 2.186 5(3) nm, c=1.171 150(13) nm, beta=94.7470(10)degrees, V=2.6229(4) nm(3), Z=4, F(000)=1 164, R(1)=0.0767, wR(2)= 0.165 5, S=1.092. The DNA-binding properties have been investigated by UV absorption, fluorescence, CD spectra and viscosity measurement. The results indicate that the complex binds to CT-DNA in an intercalative mode. Meanwhile, the cleavage reaction on plasmid DNA has been monitored by submarine gel electrophoresis. The complex could cleave circular plasmid pBR322 DNA to nicked form. CCDC: 770157.

引用

页码：649 / 654

页数：6

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