Derivatizing merocyanine dyes to balance their polarity and viscosity sensitivities for protein aggregation detection

被引：13

作者：

Bai, Yulong ^{[1
,2
]}

Huang, Yanan ^{[1
]}

Wan, Wang ^{[1
]}

Jin, Wenhan ^{[1
]}

Shen, Di ^{[1
]}

Lyu, Haochen ^{[1
]}

Zeng, Lianggang ^{[1
]}

Liu, Yu ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 98期

基金：

中国国家自然科学基金;

关键词：

Proteins;

D O I：

10.1039/d1cc05200d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Protein misfolding and aggregation processes involve local polarity and viscosity fluctuation. Herein we modulated the polarity and viscosity sensitivities of merocyanine dyes to detect protein aggregation. We demonstrated how structural modulation balanced these two fluorescence sensitivities and affected the detection of misfolded and aggregated proteins.

引用

页码：13313 / 13316

页数：4

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