Salvage Re-irradiation Options in Adult Medulloblastoma: A Case Report and Review of the Literature

被引：2

作者：

Cuccia, Francesco ^{[1
,2
]}

Mortellaro, Gianluca ^{[3
]}

Ognibene, Lucia ^{[4
]}

Craparo, Giuseppe ^{[5
]}

Lo Casto, Antonio ^{[6
]}

Ferrera, Giuseppe ^{[3
]}

机构：

[1] Univ Palermo, Radiat Oncol Sch, Palermo, Italy

[2] IRCCS Sacro Cuore Don Calabria Hosp, Adv Radiat Oncol Dept, Verona, Italy

[3] ARNAS Civ Hosp, Radiotherapy Unit, Palermo, Italy

[4] San Gaetano Radiotherapy & Nucl Med Ctr, Radiotherapy Unit, Palermo, Italy

[5] ARNAS Civ Hosp, Neuroradiol Unit, Palermo, Italy

[6] Univ Palermo, Radiat Oncol Sch, Sect Radiol DiBiMed, Palermo, Italy

来源：

IN VIVO | 2020年 / 34卷 / 03期

关键词：

Medulloblastoma; re-irradiation; adult patients; HYPOFRACTIONATED STEREOTACTIC RADIOTHERAPY; MULTIFOCAL CEREBELLAR; PROGNOSTIC-FACTORS; RECURRENT; MANAGEMENT; FRACTIONATION; CHEMOTHERAPY; RADIOSURGERY; THERAPY; RISK;

D O I：

10.21873/invivo.11903

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage re-irradiation collecting very heterogeneous series. Case Report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.

引用

页码：1283 / 1288

页数：6

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