ARMADA: Assessing reliable measurement in Alzheimer's disease and cognitive aging project methods

被引：18

作者：

Weintraub, Sandra ^{[1
,2
]}

Karpouzian-Rogers, Tatiana ^{[1
,2
]}

Peipert, John Devin ^{[3
]}

Nowinski, Cindy ^{[3
,4
]}

Slotkin, Jerry ^{[5
]}

Wortman, Katy ^{[3
]}

Ho, Emily ^{[3
]}

Rogalski, Emily ^{[1
,2
]}

Carlsson, Cynthia ^{[6
,7
]}

Giordani, Bruno ^{[8
]}

Goldstein, Felicia ^{[9
]}

Lucas, John ^{[10
]}

Manly, Jennifer J. ^{[11
]}

Rentz, Dorene ^{[12
,13
]}

Salmon, David ^{[14
]}

Snitz, Beth ^{[15
]}

Dodge, Hiroko H. ^{[16
]}

Riley, Michaela ^{[1
]}

Eldes, Fatima ^{[1
]}

Ustsinovich, Vitali ^{[3
]}

Gershon, Richard ^{[3
]}

机构：

[1] Northwestern Univ, Mesulam Ctr Cognit Neurol & Alzheimers Dis, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Psychiat & Behav Sci, Feinberg Sch Med, Chicago, IL USA

[3] Northwestern Univ, Dept Med Social Sci, Feinberg Sch Med, Chicago, IL USA

[4] Northwestern Univ, Dept Neurol, Feinberg Sch Med, Chicago, IL USA

[5] Univ Delaware, Ctr Hlth Assessment Res & Translat, Delaware, OH USA

[6] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI USA

[7] Wisconsin Alzheimers Dis Res Ctr, Madison, WI USA

[8] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[9] Emory Univ, Dept Neurol, Atlanta, GA USA

[10] Mayo Clin, Dept Psychiat & Psychol, Jacksonville, FL USA

[11] Columbia Univ, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA

[12] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[13] Harvard Med Sch, Womens Hosp, Boston, MA USA

[14] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[15] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[16] Oregon Hlth & Sci Univ, Dept Neurol, Layton Aging & Alzheimers Dis Ctr, Portland, OR 97201 USA

来源：

ALZHEIMERS & DEMENTIA | 2022年 / 18卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; cognition; dementia; mild cognitive impairment; neuropsychology; NIH Toolbox; DATA SET UDS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; NIH TOOLBOX; RISK-FACTOR; IMPAIRMENT; DEMENTIA; RECOMMENDATIONS; DECLINE;

D O I：

10.1002/alz.12497

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Early detection of cognitive decline in older adults is a public health priority. Advancing Reliable Measurement in Alzheimer's Disease and Cognitive Aging (ARMADA), a multisite study, is validating cognition, emotion, motor, and sensory modules of the National Institutes of Health Toolbox for Assessment of Neurological and Behavioral Function (NIHTB) in the aging spectrum from cognitively normal to dementia of the Alzheimer's type (DAT). Methods: Participants 65 to 85 years old, in demographic groups racially proportional to the general US population, are recruited in one of three groups to validate the NIHTB: cognitively normal, amnestic mild cognitive impairment (aMCI), or mild DAT. Additional special emphasis cohorts include (1) Blacks in the three clinical groups; (2) Spanish-speakers in the three clinical groups; (3) cognitively normal, population-proportional, over age 85. Discussion: Longitudinal study will determine whether NIHTB can predict cognitive decline and is associated with Alzheimer's disease biomarkers. Here, we detail the methods for the ARMADA study.

引用

页码：1449 / 1460

页数：12

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