Curcumin modifies Apcmin apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apcmin mice

被引:50
作者
Collett, GP
Robson, CN
Mathers, JC
Campbell, FC
机构
[1] Queens Univ Belfast, Ctr Canc, Dept Surg, Belfast BT12 6BJ, Antrim, North Ireland
[2] Newcastle Univ, Dept Biol & Nutr Sci, Human Nutr Res Ctr, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[3] Newcastle Univ, Dept Surg, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
关键词
D O I
10.1093/carcin/22.5.821
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Curcumin, the active ingredient of the rhizome of Curcuma longa, promotes apoptosis and may have chemopreventive properties. This study investigates the effects of curcumin on apoptosis and tumorigenesis in male Apc(min) mice treated with the human dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Intestinal epithelial apoptotic index in response to PhIP treatment was approximately twice as great in the wild-type C57BL/6 APC(+/+) strain than in Apc(min) mice (3.7% Apc(+/+) versus 1.9% Apc(min); P < 0.001). PhIP promoted tumour formation in Apc(min) proximal small intestine (4.6 tumours per mouse, PhIP treated versus 2.1 tumours per mouse, control untreated; P < 0.05). Curcumin enhanced PhIP-induced apoptosis (4.0% curcumin + PhIP versus 2.1% PhIP alone; P < 0.01) and inhibited PhIP-induced tumorigenesis in the proximal small intestine of Apc(min) mice (2.2 tumours per mouse, curcumin + PhIP versus 4.6 tumours per mouse PhIP alone; P < 0.05). This study shows that the Apc(min) genotype is associated with resistance to PhIP-induced apoptosis in intestinal epithelium. Curcumin attenuates Apc(min) resistance to PhIP-induced apoptosis and inhibits PhIP-induced tumorigenesis in proximal Apc(min) mouse small intestine.
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页码:821 / 825
页数:5
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