Kinetics of maternal antibodies against rubella and varicella in infants

被引：69
作者：
Leuridan, E. [1 ]
Hens, N. [2 ,3 ]
Hutse, V.
Aerts, M. [2 ]
van Damme, P. [1 ]
机构：
[1] Univ Antwerp, Fac Med, Vaccine & Infect Dis Inst, Ctr Evaluat Vaccinat, B-2610 Antwerp, Belgium
[2] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinforrnat I BIOS, Hasselt, Belgium
[3] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis, Vaccine & Infect Dis Inst, B-2610 Antwerp, Belgium
来源：
VACCINE | 2011年 / 29卷 / 11期
关键词：
Maternal antibodies; Rubella; Varicella; Vaccination; ZOSTER-VIRUS; CHILDBEARING AGE; IMMUNOGLOBULIN-G; MEASLES; MUMPS; WOMEN; VACCINE; IMMUNITY; SEROPREVALENCE; SEROEPIDEMIOLOGY;
D O I：
10.1016/j.vaccine.2010.06.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Kinetics of maternal rubella and varicella antibodies in 213 mother-infant pairs are described in a longitudinal study in Belgium. Blood samples are taken at 7 time points (week 36 of pregnancy, birth (cord), 1, 3, 6, 9, and 12 months), and analyzed for anti-rubella IgG and anti-varicella IgG by enzyme linked immunosorbent assay (ELISA). A generalized exponential model is used to analyse maternal antibody decay in infants. Model based, the mean duration of passive immunity is 2.1 months for rubella and 2.4 months for varicella. Infants are susceptible at young age for rubella, a disease with high vaccination coverage, as well as for varicella, an endemic disease in Western Europe. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：2222 / 2226
页数：5
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