The peculiarities of neurological and cognitive disturbances in dependence of brain lesions localization, volume and brain atrophy in multiple sclerosis patients

被引：0

作者：

Mineev, K. K. ^{[1
]}

Prakhova, L. N. ^{[1
]}

Ilves, A. G. ^{[1
]}

Kataeva, G. V. ^{[1
]}

Petrov, A. M. ^{[1
]}

Reznikova, T. N. ^{[1
]}

Pozdnyakov, A. V. ^{[1
]}

Stolyarov, I. D. ^{[1
]}

机构：

[1] Ctr Res Inst Roentgenol & Radiol, St Petersburg, Russia

来源：

ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2007年

关键词：

multiple sclerosis; brain atrophy; cognitive dysfunctions; T2-lesion volume;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The objective of the study was to investigate neurological and cognitive disturbances and their relationship with the localization and volume of brain lesions and brain atrophy in patients with multiple sclerosis. Sixty-five patients with relapsing remitted multiple sclerosis were examined. A neurological assessment included FS, EDSS scores and neurophysiological tests. All subjects underwent 1.5-T MRI. Brain atrophy (brain parenchyma volume) and total T2 lesion volume were calculated as percentage of intracranial volume. The neurological disability depended on the development of brain parenchymal volume atrophy and total volume of infratentorial T2-lesions. Cognitive disturbance were found in 89% of patients. Cognitive impairment was related to the progression of the global brain atrophy and the total T2-lesion volume in the dominant hemisphere.

引用

页码：46 / 49

页数：4

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