Vitamin D in defense of the human immune response

被引：113

作者：

Adams, Johns S. ^{[1
]}

Liu, Philip T. ^{[2
,3
]}

Chun, Rene ^{[1
]}

Modlin, Robert L. ^{[2
,3
]}

Hewison, Martin ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Burns & Allen Res Inst, Diabet & Metab Res Inst, Div Endocrinol, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Dermatol, Los Angeles, CA USA

来源：

SKELETAL BIOLOGY AND MEDICINE, PT B: DISEASE MECHANISMS AND THERAPEUTIC CHALLENGES | 2007年 / 1117卷

关键词：

vitamin D; innate immunity; adaptive immunity; macrophage; dendritic cell; tuberculosis;

D O I：

10.1196/annals.1402.036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Defensin is a generic name reserved for an endogenously synthesized antimicrobial agent. The purpose of this review is to describe a series of discoveries that led to the proposal that 25-hydroxylated metabolites of vitamin D are key, intracellular regulators of the synthesis and action of naturally occurring defensin molecules against bacterial antigens. The discussion will (1) highlight the basic elements of human immune response that is responsive to vitamin D, (2) recount work relevant to the extrarenal expression of the vitamin D-1-hydroxlase (CYP27b1) in the macrophage as an initiator of the innate immune response, and (3) describe recent work on the relevance of the vitamin D intracrine-autocrine-paracrine system in a model of a common and devastating human disease, tuberculosis.

引用

页码：94 / 105

页数：12

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