Randomized Clinical Trials in Gastrointestinal stromal Tumors

被引:0
作者
Liu, Yang [1 ]
von Mehren, Margaret [1 ]
机构
[1] Fox Chase Canc Ctr, Dept Hematol Oncol, 333 Cottman Ave, Philadelphia, PA 19111 USA
关键词
Gastrointestinal stromal tumors; Imatinib; Tyrosine kinase inhibitors; FRENCH SARCOMA GROUP; SOFT-TISSUE; PHASE-III; IMATINIB; FAILURE; ADJUVANT; PROGRESSION; NILOTINIB; EFFICACY; THERAPY;
D O I
10.1016/j.soc.2017.05.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This review explores the current standard of care for the surgical management of gastrointestinal stromal tumors, highlights important studies in the medical management of gastrointestinal stromal tumors, and provides guidance in how these studies changed the standard of care in clinical practice.
引用
收藏
页码:545 / +
页数:14
相关论文
共 18 条
[1]   Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: A randomized controlled open-label trial [J].
Adenis, A. ;
Blay, J. -Y. ;
Bui-Nguyen, B. ;
Bouche, O. ;
Bertucci, F. ;
Isambert, N. ;
Bompas, E. ;
Chaigneau, L. ;
Domont, J. ;
Ray-Coquard, I. ;
Blesius, A. ;
Van Tine, B. A. ;
Bulusu, V. R. ;
Dubreuil, P. ;
Mansfield, C. D. ;
Acin, Y. ;
Moussy, A. ;
Hermine, O. ;
Le Cesne, A. .
ANNALS OF ONCOLOGY, 2014, 25 (09) :1762-1769
[2]   Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033 [J].
Blanke, Charles D. ;
Rankin, Cathryn ;
Demetri, George D. ;
Ryan, Christopher W. ;
von Mehren, Margaret ;
Benjamin, Robert S. ;
Raymond, A. Kevin ;
Bramwell, Vivien H. C. ;
Baker, Laurence H. ;
Maki, Robert G. ;
Tanaka, Michael ;
Hecht, J. Randolph ;
Heinrich, Michael C. ;
Fletcher, Christopher D. M. ;
Crowley, John J. ;
Borden, Ernest C. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (04) :626-632
[3]  
Blay JY, 2007, J CLIN ONCOL, V25, P1107, DOI 10.1200/JCO.2006.09.0183
[4]   Nilotinib versus imatinib as first-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trial [J].
Blay, Jean-Yves ;
Shen, Lin ;
Kang, Yoon-Koo ;
Rutkowski, Piotr ;
Qin, Shukui ;
Nosov, Dmitry ;
Wan, Desen ;
Trent, Jonathan ;
Srimuninnimit, Vichien ;
Papai, Zsuzsanna ;
Le Cesne, Axel ;
Novick, Steven ;
Taningco, Lilia ;
Mo, Shuyuan ;
Green, Steven ;
Reichardt, Peter ;
Demetri, George D. .
LANCET ONCOLOGY, 2015, 16 (05) :550-560
[5]   Time to Definitive Failure to the First Tyrosine Kinase Inhibitor in Localized GI Stromal Tumors Treated With Imatinib As an Adjuvant: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup Randomized Trial in Collaboration With the Australasian Gastro-Intestinal Trials Group, UNICANCER, French Sarcoma Group, Italian Sarcoma Group, and Spanish Group for Research on Sarcomas [J].
Casali, Paolo G. ;
Le Cesne, Axel ;
Velasco, Andres Poveda ;
Kotasek, Dusan ;
Rutkowski, Piotr ;
Hohenberger, Peter ;
Fumagalli, Elena ;
Judson, Ian R. ;
Italiano, Antoine ;
Gelderblom, Hans ;
Adenis, Antoine ;
Hartmann, Jorg T. ;
Duffaud, Florence ;
Goldstein, David ;
Broto, Javier M. ;
Gronchi, Alessandro ;
Dei Tos, Angelo P. ;
Marreaud, Sandrine ;
van der Graaf, Winette T.A. ;
Zalcberg, John R. ;
Litiere, Saskia ;
Blay, Jean-Yves .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (36) :4276-4283
[6]   Pathologic and Molecular Features Correlate With Long-Term Outcome After Adjuvant Therapy of Resected Primary GI Stromal Tumor: The ACOSOG Z9001 Trial [J].
Corless, Christopher L. ;
Ballman, Karla V. ;
Antonescu, Cristina R. ;
Kolesnikova, Violetta ;
Maki, Robert G. ;
Pisters, Peter W. T. ;
Blackstein, Martin E. ;
Blanke, Charles D. ;
Demetri, George D. ;
Heinrich, Michael C. ;
von Mehren, Margaret ;
Patel, Shreyaskumar ;
McCarter, Martin D. ;
Owzar, Kouros ;
DeMatteo, Ronald P. .
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15) :1563-U61
[7]   Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors [J].
Demetri, GD ;
von Mehren, M ;
Blanke, CD ;
Van den Abbeele, AD ;
Eisenberg, B ;
Roberts, PJ ;
Heinrich, MC ;
Tuveson, DA ;
Singer, S ;
Janicek, M ;
Fletcher, JA ;
Silverman, SG ;
Silberman, SL ;
Capdeville, R ;
Kiese, B ;
Peng, B ;
Dimitrijevic, S ;
Druker, BJ ;
Corless, C ;
Fletcher, CDM ;
Joensuu, H .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (07) :472-480
[8]   Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial [J].
Demetri, George D. ;
van Oosterom, Allan T. ;
Garrett, Christopher R. ;
Blackstein, Martin E. ;
Shah, Manisha H. ;
Verweij, Jaap ;
McArthur, Grant ;
Judson, Ian R. ;
Heinrich, Michael C. ;
Morgan, Jeffrey A. ;
Desai, Jayesh ;
D Fletcher, Christopher ;
George, Suzanne ;
Bello, Carlo L. ;
Huang, Xin ;
Baum, Charles M. ;
Casali, Paolo G. .
LANCET, 2006, 368 (9544) :1329-1338
[9]   Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial [J].
Demetri, George D. ;
Reichardt, Peter ;
Kang, Yoon-Koo ;
Blay, Jean-Yves ;
Rutkowski, Piotr ;
Gelderblom, Hans ;
Hohenberger, Peter ;
Leahy, Michael ;
von Mehren, Margaret ;
Joensuu, Heikki ;
Badalamenti, Giuseppe ;
Blackstein, Martin ;
Le Cesne, Axel ;
Schoffski, Patrick ;
Maki, Robert G. ;
Bauer, Sebastian ;
Binh Bui Nguyen ;
Xu, Jianming ;
Nishida, Toshirou ;
Chung, John ;
Kappeler, Christian ;
Kuss, Iris ;
Laurent, Dirk ;
Casali, Paolo G. .
LANCET, 2013, 381 (9863) :295-302
[10]   One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor A Randomized Trial [J].
Joensuu, Heikki ;
Eriksson, Mikael ;
Hall, Kirsten Sundby ;
Hartmann, Joerg T. ;
Pink, Daniel ;
Schuette, Jochen ;
Ramadori, Giuliano ;
Hohenberger, Peter ;
Duyster, Justus ;
Al-Batran, Salah-Eddin ;
Schlemmer, Marcus ;
Bauer, Sebastian ;
Wardelmann, Eva ;
Sarlomo-Rikala, Maarit ;
Nilsson, Bengt ;
Sihto, Harri ;
Monge, Odd R. ;
Bono, Petri ;
Kallio, Raija ;
Vehtari, Aki ;
Leinonen, Mika ;
Alvegard, Thor ;
Reichardt, Peter .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (12) :1265-1272