Bioactive Compounds from Marine Bacteria and Fungi

被引：245

作者：

Debbab, Abdessamad ^{[1
]}

Aly, Amal H. ^{[1
]}

Lin, Wen H. ^{[2
]}

Proksch, Peter ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Dusseldorf, Germany

[2] Peking Univ, Hlth Sci Ctr, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

MICROBIAL BIOTECHNOLOGY | 2010年 / 3卷 / 05期

关键词：

NATURAL-PRODUCTS; LYCOGALA-EPIDENDRUM; ASPERGILLUS SP; METABOLITES; DERIVATIVES; PENICILLIUM; 2,4-DIACETYLPHLOROGLUCINOL; MICROORGANISMS; BIOSYNTHESIS; ACTINOMYCETE;

D O I：

10.1111/j.1751-7915.2010.00179.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Marine bacteria and fungi are of considerable importance as new promising sources of a huge number of biologically active products. Some of these marine species live in a stressful habitat, under cold, light-less and high pressure conditions. Surprisingly, a large number of species with high diversity survive under such conditions and produce fascinating and structurally complex natural products. Up till now, only a small number of microorganisms have been investigated for bioactive metabolites, yet a huge number of active substances with some of them featuring unique structural skeletons have been isolated. This review covers new biologically active natural products published recently (2007-09) and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.

引用

页码：544 / 563

页数：20

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