Drug repurposing: a new front in the war against Staphylococcus aureus

被引：19

作者：

Das, Swetarka ^{[1
]}

Dasgupta, Arunava ^{[1
]}

Chopra, Sidharth ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Dept Microbiol, Lucknow 226031, Uttar Pradesh, India

来源：

FUTURE MICROBIOLOGY | 2016年 / 11卷 / 08期

关键词：

antibiotics; drug repurposing; MRSA; Staphylococcus aureus; INFECTIONS; AURANOFIN; CELECOXIB; AGENTS;

D O I：

10.2217/fmb-2016-0021

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcus aureus continues its domination of worldwide bacterial infection rates, thereby remaining a pathogen of significant public health interest. A major reason for its continued success is its ability to acquire and maintain diverse drug resistance mechanisms, leading to a paucity of antimicrobials active against it, concomitantly leading to a continuous search for new antimicrobial agents. However, with the withdrawal of the major pharmaceutical firms from the anti-infective area, drug repurposing has provided a potential boost to the drug pipeline. In this review, we provide an overview of the currently approved drugs with repurposing potential against Staphylococcus aureus, thus augmenting the classical drug discovery pathway.

引用

页码：1091 / 1099

页数：9

共 28 条

[1] Auranofin efficacy against MDR Streptococcus pneumoniae and Staphylococcus aureus infections [J].

Aguinagalde, Leire ;

Diez-Martinez, Roberto ;

Yuste, Jose ;

Royo, Inmaculada ;

Gil, Carmen ;

Lasa, Inigo ;

Martin-Fontecha, Mar ;

Marin-Ramos, Nagore Isabel ;

Ardanuy, Carmen ;

Linares, Josefina ;

Garcia, Pedro ;

Garcia, Ernesto ;

Sanchez-Puelles, Jose M. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 70 (09) :2608-2617

[2] Inhibition of Schistosoma mansoni Thioredoxin-glutathione Reductase by Auranofin STRUCTURAL AND KINETIC ASPECTS [J].

Angelucci, Francesco ;

Sayed, Ahmed A. ;

Williams, David L. ;

Boumis, Giovanna ;

Brunori, Maurizio ;

Dimastrogiovanni, Daniela ;

Miele, Adriana E. ;

Pauly, Frida ;

Bellelli, Andrea .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (42) :28977-28985

[3] Celecoxib Sensitizes Staphylococcus aureus to Antibiotics in Macrophages by Modulating SIRT1 [J].

Annamanedi, Madhavi ;

Kalle, Arunasree M. .

PLOS ONE, 2014, 9 (06)

[4]

[Anonymous], 2015, ANT CURR CLIN DEV

[5] Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus [J].

Bode, Lonneke G. M. ;

Kluytmans, Jan A. J. W. ;

Wertheim, Heiman F. L. ;

Bogaers, Diana ;

Vandenbroucke-Grauls, Christina M. J. E. ;

Roosendaal, Robert ;

Troelstra, Annet ;

Box, Adrienne T. A. ;

Voss, Andreas ;

van der Tweel, Ingeborg ;

van Belkum, Alex ;

Verbrugh, Henri A. ;

Vos, Margreet C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (01) :9-17

[6] Repurposing with a Difference [J].

Boguski, Mark S. ;

Mandl, Kenneth D. ;

Sukhatme, Vikas P. .

SCIENCE, 2009, 324 (5933) :1394-1395

[7] 10 x '20 Progress-Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America [J].

Boucher, Helen W. ;

Talbot, George H. ;

Benjamin, Daniel K., Jr. ;

Bradley, John ;

Guidos, Robert J. ;

Jones, Ronald N. ;

Murray, Barbara E. ;

Bonomo, Robert A. ;

Gilbert, David .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (12) :1685-1694

[8] Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide [J].

Corriden, Ross ;

Hollands, Andrew ;

Olson, Joshua ;

Derieux, Jaclyn ;

Lopez, Justine ;

Chang, John T. ;

Gonzalez, David J. ;

Nizet, Victor .

NATURE COMMUNICATIONS, 2015, 6

[9] Statins and Antimicrobial Effects: Simvastatin as a Potential Drug against Staphylococcus aureus Biofilm [J].

Graziano, Talita Signoreti ;

Cuzzullin, Maria Claudia ;

Franco, Gilson Cesar ;

Schwartz-Filho, Humberto Osvaldo ;

de Andrade, Eduardo Dias ;

Groppo, Francisco Carlos ;

Cogo-Mueller, Karina .

PLOS ONE, 2015, 10 (05)

[10] Factors Affecting Wound Healing [J].

Guo, S. ;

DiPietro, L. A. .

JOURNAL OF DENTAL RESEARCH, 2010, 89 (03) :219-229

← 1 2 3 →