Genetika plus : precision medicine solutions for mental health

被引：1

作者：

Albeldas, Claudia ^{[1
]}

Cohen, Niv ^{[1
]}

Natan, Sari ^{[1
]}

Askari, Nadav ^{[1
]}

Laifenfeld, Daphna ^{[1
]}

Solal, Talia Cohen ^{[1
]}

机构：

[1] GenetikaPlus Ltd, 126 Yigal Alon, IL-6744332 Tel Aviv, Israel

来源：

PHARMACOGENOMICS | 2022年 / 23卷 / 10期

关键词：

depression; mental health; neurons; pharmacogenetics; stem cells;

D O I：

10.2217/pgs-2022-0053

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Genetika+ is developing a precision medicine tool to optimize the treatment of depression by helping physicians find the best drug therapy for their patients. The tool builds on traditional pharmacogenetics, introducing a 'brain-in-a-dish' screening platform for each patient that will overcome the challenge of limited pharmacodynamic knowledge of pharmacogenetics (PGx). In addition to PGx, our platform integrates patient data with innovative blood-derived patient neurons to test all categories of antidepressants and predict the best drug for each patient. This offers patients optimal drug treatment, allowing a faster response, fewer side effects and lower dosing.

引用

页码：571 / 574

页数：4

共 9 条

[1] Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response
Avior, Yishai
Ron, Shiri
Kroitorou, Dana
Albeldas, Claudia
Lerner, Vitaly
Corneo, Barbara
Nitzan, Erez
Laifenfeld, Daphna
Solal, Talia Cohen
[J]. TRANSLATIONAL PSYCHIATRY, 2021, 11 (01)
[2] Pharmacogenetics of drug-metabolizing enzymes: implications for a safer and more effective drug therapy
Ingelman-Sundberg, M
Rodriguez-Antona, C
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1460) : 1563 - 1570
[3] Remission, dropouts, and adverse drug reaction rates in major depressive disorder: a meta-analysis of head-to-head trials
Machado, Marcio
Iskedjian, Michael
Ruiz, Ines
Einarson, Thomas R.
[J]. CURRENT MEDICAL RESEARCH AND OPINION, 2006, 22 (09) : 1825 - 1837
[4] Depression
Malhi, Gin S.
Mann, J. John
[J]. LANCET, 2018, 392 (10161) : 2299 - 2312
[5] Rush AJ, 2007, J CLIN PSYCHIAT, V68, P4
[6] The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Trial: A Review
Sinyor, Mark
Schaffer, Ayal
Levitt, Anthony
[J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2010, 55 (03): : 126 - 135
[7] Steinberg JW., 2020, Journal of Health Sciences Management and Public Health, V1, P44
[8] Vos T, 2013, LANCET, V381, P628
[9] World Health Organization, EUR PROGR WORK

← 1 →