Diabetes Mellitus Is Associated with Shortened Activated Partial Thromboplastin Time and Increased Fibrinogen Values

被引：51
|
作者：
Zhao, Ying [1 ]
Zhang, Jie [1 ]
Zhang, Juanwen [1 ]
Wu, Jianping [1 ]
机构：
[1] Zhejiang Univ, Dept Lab Med, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
来源：
PLOS ONE | 2011年 / 6卷 / 01期
关键词：
FASTING PLASMA-GLUCOSE; COAGULATION ACTIVATION; CARDIOVASCULAR-DISEASE; HYPERGLYCEMIA; RISK; THROMBOEMBOLISM; COMPLICATIONS; MANAGEMENT; DIAGNOSIS;
D O I：
10.1371/journal.pone.0016470
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Objective: This study was designed to examine the relationship between shortened activated partial thromboplastin time (APTT) and increased fibrinogen values with diabetes mellitus. Methods: APTT, prothrombin time (PT), fibrinogen, fasting plasma glucose (FPG) and glycosylated hemoglobin A1c (HbA1c) levels were measured in 1,300 patients. Patients were divided into three groups according to their HbA1c and FPG levels. Results: When participants were grouped according to their HbA1c levels, we found significantly shorter APTT values (26.9+/-65.6 s) and increased fibrinogen levels (3.1, 1.9-6.3 g/L) in the diabetes group when compared with the other two groups. When participants were grouped according to their FPG levels, we found significantly shorter APTT values (26.9+/-66.2 s) and increased fibrinogen levels (3.1, 1.8-6.2 g/L) in the diabetes group when compared with the euglycemic group. Conclusions: Shorter APTT and increased fibrinogen levels might be useful hemostatic markers in patients with diabetes and in patients at high risk for diabetes.
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页数：4
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