Evidence Accumulation in Obsessive-Compulsive Disorder: the Role of Uncertainty and Monetary Reward on Perceptual Decision-Making Thresholds

被引:76
作者
Banca, Paula [1 ,2 ,3 ]
Vestergaard, Martin D. [4 ]
Rankov, Vladan [1 ]
Baek, Kwangyeol [1 ]
Mitchell, Simon [1 ]
Lapa, Tatyana [1 ]
Castelo-Branco, Miguel [3 ]
Voon, Valerie [1 ,5 ,6 ]
机构
[1] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 0QQ, England
[2] Univ Coimbra, Ctr Neurosci & Cell Biol, PhD Programme Expt Biol & Biomed, P-3000 Coimbra, Portugal
[3] Univ Coimbra, Inst Biomed Imaging & Life Sci, P-3000 Coimbra, Portugal
[4] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 0QQ, England
[5] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 0QQ, England
[6] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England
基金
英国惠康基金;
关键词
DEEP BRAIN-STIMULATION; REFLECTION IMPULSIVITY; ANTERIOR CINGULATE; MEMORY; CONCLUSIONS; BEHAVIOR; MODEL; TASK; BIAS;
D O I
10.1038/npp.2014.303
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The compulsive behaviour underlying obsessive-compulsive disorder (OCD) may be related to abnormalities in decision-making. The inability to commit to ultimate decisions, for example, patients unable to decide whether their hands are sufficiently clean, may reflect failures in accumulating sufficient evidence before a decision. Here we investigate the process of evidence accumulation in OCD in perceptual discrimination, hypothesizing enhanced evidence accumulation relative to healthy volunteers. Twenty-eight OCD patients and thirty-five controls were tested with a low-level visual perceptual task (random-dot-motion task, RDMT) and two response conflict control tasks. Regression analysis across different motion coherence levels and Hierarchical Drift Diffusion Modelling (HDDM) were used to characterize response strategies between groups in the RDMT. Patients required more evidence under high uncertainty perceptual contexts, as indexed by longer response time and higher decision boundaries. HDDM, which defines a decision when accumulated noisy evidence reaches a decision boundary, further showed slower drift rate towards the decision boundary reflecting poorer quality of evidence entering the decision process in patients under low uncertainty. With monetary incentives emphasizing speed and penalty for slower responses, patients decreased the decision thresholds relative to controls, accumulating less evidence in low uncertainty. These findings were unrelated to visual perceptual deficits and response conflict. This study provides evidence for impaired decision-formation processes in OCD, with a differential influence of high and low uncertainty contexts on evidence accumulation (decision threshold) and on the quality of evidence gathered (drift rates). It further emphasizes that OCD patients are sensitive to monetary incentives heightening speed in the speed-accuracy tradeoff, improving evidence accumulation.
引用
收藏
页码:1192 / 1202
页数:11
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