Maternal HIV infection influences the microbiome of HIV-uninfected infants

被引：91

作者：

Bender, Jeffrey M. ^{[1
,2
]}

Li, Fan ^{[1
]}

Martelly, Shoria ^{[3
]}

Byrt, Erin ^{[4
,5
]}

Rouzier, Vanessa ^{[3
]}

Leo, Marguerite ^{[3
]}

Tobin, Nicole ^{[1
]}

Pannaraj, Pia S. ^{[1
]}

Adisetiyo, Helty ^{[1
]}

Rollie, Adrienne ^{[1
]}

Santiskulvong, Chintda ^{[1
]}

Wang, Shaun ^{[4
]}

Autran, Chloe ^{[6
]}

Bode, Lars ^{[6
]}

Fitzgerald, Daniel ^{[5
]}

Kuhn, Louise ^{[4
]}

Aldrovandi, Grace M. ^{[1
,2
]}

机构：

[1] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA

[3] GHESKIO Ctr, Haitian Grp Study Kaposis Sarcoma & Opportunist I, Port Au Prince 15727, Ouest, Haiti

[4] Columbia Univ, Dept Epidemiol & Biostat, New York, NY 10032 USA

[5] Weill Cornell Med Coll, Ctr Global Hlth, New York, NY 10065 USA

[6] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2016年 / 8卷 / 349期

关键词：

HUMAN-MILK OLIGOSACCHARIDES; INCREASED RISK; CHILDREN BORN; GUT MICROBIOME; BREAST-MILK; MORTALITY; MOTHERS; DISEASE; PROBIOTICS; MORBIDITY;

D O I：

10.1126/scitranslmed.aaf5103

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.

引用

页数：12

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