Neural stem cells, tumour stem cells and brain tumours: Dangerous relationships?

被引：23
作者：
Sutter, Reto [1 ]
Yadirgi, Gokhan [1 ]
Marino, Silvia [1 ]
机构：
[1] Queen Mary Sch Med & Dentistry, Barts & London, Inst Cell & Mol Sci, London E1 2AT, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2007年 / 1776卷 / 02期
关键词：
neural stem cell; tumour stem cell; brain tumour; neurogenesis; molecular pathway; mouse model;
D O I：
10.1016/j.bbcan.2007.07.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neural stem cells (NSC) have been implicated not only in brain development and neurogenesis but also in tumourigenesis. Brain tumour stem cells (BTSC) have been isolated from several paediatric or adult human brain tumours, however their origin is still disputed. This review discusses the normal role of NSC in the adult mammalian brain and their anatomical location. It compares the molecular characteristics and the biological behaviour of NSC/BTSC, and describes the molecular pathways involved in controlling self-renewal and maintenance of adult NSC/BTSC and brain tumour development. It also assesses the current hypotheses about the origin of BTSC and the clinical consequences. (c) 2007 Elsevier B.V. All rights reserved.
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收藏
页码：125 / 137
页数：13
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