Solid-phase synthesis of oligonucleotides containing a bipyridine ligand at the 3′-3′ inversion of polarity site

被引：3

作者：

Galeone, A ^{[1
]}

Mayol, L ^{[1
]}

Oliviero, G ^{[1
]}

Rigano, D ^{[1
]}

Varra, M ^{[1
]}

机构：

[1] Univ Naples Federico II, Dip Chim Sostanze Nat, I-80131 Naples, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00673-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of a solid support useful for the synthesis of oligonucleotides with a 3'-3' inversion of polarity, via a linker containing a chelating molecule, namely 2,2'-bipyridine, is described. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：383 / 386

页数：4

共 18 条

[11] SEQUENCE-SPECIFIC CLEAVAGE OF DOUBLE HELICAL DNA BY TRIPLE HELIX FORMATION
MOSER, HE
DERVAN, PB
[J]. SCIENCE, 1987, 238 (4827) : 645 - 650
[12] Pyle A.M., 1990, PROG INORG CHEM, V38, P413
[13] CHEMICAL NUCLEASES
SIGMAN, DS
MAZUMDER, A
PERRIN, DM
[J]. CHEMICAL REVIEWS, 1993, 93 (06) : 2295 - 2316
[14] SEQUENCE-SPECIFIC RECOGNITION AND MODIFICATION OF DOUBLE-HELICAL DNA BY OLIGONUCLEOTIDES
THUONG, NT
HELENE, C
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1993, 32 (05) : 666 - 690
[15] ANTISENSE OLIGONUCLEOTIDES - A NEW THERAPEUTIC PRINCIPLE
UHLMANN, E
PEYMAN, A
[J]. CHEMICAL REVIEWS, 1990, 90 (04) : 543 - 584
[16] WICKSTROM E, 1991, PROSPECT ANTISENSE N
[17] A 2,2′-bipyridine ligand for incorporation into oligodeoxynucleotides:: synthesis, stability and fluorescence properties of ruthenium-DNA complexes
Wiederholt, K
McLaughlin, LW
[J]. NUCLEIC ACIDS RESEARCH, 1999, 27 (12) : 2487 - 2493
[18] RECOGNITION OF ALTERNATING OLIGOPURINE OLIGOPYRIMIDINE TRACTS OF DNA BY OLIGONUCLEOTIDES WITH BASE-TO-BASE LINKAGES
ZHOU, BW
MARCHAND, C
ASSELINE, U
THUONG, NT
SUN, JS
GARESTIER, T
HELENE, C
[J]. BIOCONJUGATE CHEMISTRY, 1995, 6 (05) : 516 - 523

← 1 2 →