Nintedanib and Pirfenidone New Antifibrotic Treatments Indicated for Idiopathic Pulmonary Fibrosis Offer Hopes and Raises Questions

被引:144
作者
Raghu, Ganesh [1 ]
Selman, Moises [2 ]
机构
[1] Univ Washington, Med Ctr, Seattle, WA 98195 USA
[2] Inst Nacl Enfermedad Resp, Mexico City, DF, Mexico
关键词
PLACEBO-CONTROLLED TRIAL; RANDOMIZED-TRIAL; ACETYLCYSTEINE; BOSENTAN; EFFICACY;
D O I
10.1164/rccm.201411-2044ED
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:252 / 254
页数:3
相关论文
共 19 条
[1]  
Amer Thoracic Soc, 2000, AM J RESP CRIT CARE, V161, P646
[2]   Imatinib Treatment for Idiopathic Pulmonary Fibrosis Randomized Placebo-controlled Trial Results [J].
Daniels, Craig E. ;
Lasky, Joseph A. ;
Limper, Andrew H. ;
Mieras, Kathleen ;
Gabor, Edith ;
Schroeder, Darrell R. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181 (06) :604-610
[3]   High-dose acetylcysteine in idiopathic pulmonary fibrosis [J].
Demedts, M ;
Behr, J ;
Buhl, R ;
Costabel, U ;
Dekhuijzen, R ;
Jansen, HM ;
MacNee, W ;
Thomeer, M ;
Wallaert, B ;
Laurent, F ;
Nicholson, AG ;
Verbeken, EK ;
Verschakelen, J ;
Flower, CDR ;
Capron, F ;
Petruzzelli, S ;
De Vuyst, P ;
van den Bosch, JMM ;
Rodriguez-Becerra, E ;
Corvasce, G ;
Lankhorst, I ;
Sardina, M ;
Montanari, M .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (21) :2229-2242
[4]   BUILD-1:: A randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis [J].
King, Talmadge E., Jr. ;
Behr, Juergen ;
Brown, Kevin K. ;
du Bois, Roland M. ;
Lancaster, Lisa ;
de Andrade, Joao A. ;
Staehler, Gerd ;
Leconte, Isabelle ;
Roux, Sebastien ;
Raghu, Ganesh .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (01) :75-81
[5]   A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis [J].
King, Talmadge E., Jr. ;
Bradford, Williamson Z. ;
Castro-Bernardini, Socorro ;
Fagan, Elizabeth A. ;
Glaspole, Ian ;
Glassberg, Marilyn K. ;
Gorina, Eduard ;
Hopkins, Peter M. ;
Kardatzke, David ;
Lancaster, Lisa ;
Lederer, David J. ;
Nathan, Steven D. ;
Pereira, Carlos A. ;
Sahn, Steven A. ;
Sussman, Robert ;
Swigris, Jeffrey J. ;
Noble, Paul W. .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (22) :2083-2092
[6]   BUILD-3: A Randomized, Controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis [J].
King, Talmadge E., Jr. ;
Brown, Kevin K. ;
Raghu, Ganesh ;
du Bois, Roland M. ;
Lynch, David A. ;
Martinez, Fernando ;
Valeyre, Dominique ;
Leconte, Isabelle ;
Morganti, Adele ;
Roux, Sebastien ;
Behr, Juergen .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 184 (01) :92-99
[7]   Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial [J].
King, Talmadge E., Jr. ;
Albera, Carlo ;
Bradford, Williamson Z. ;
Costabel, Ulrich ;
Hormel, Phil ;
Lancaster, Lisa ;
Noble, Paul W. ;
Sahn, Steven A. ;
Szwarcberg, Javier ;
Thomeer, Michiel ;
Valeyre, Dominique ;
du Bois, Roland M. .
LANCET, 2009, 374 (9685) :222-228
[8]   Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis [J].
Martinez, Fernando J. ;
de Andrade, Joao A. ;
Anstrom, Kevin J. ;
King, Talmadge E., Jr. ;
Raghu, Ganesh .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (22) :2093-2101
[9]   Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials [J].
Noble, Paul W. ;
Albera, Carlo ;
Bradford, Williamson Z. ;
Costabel, Ulrich ;
Glassberg, Marilyn K. ;
Kardatzke, David ;
King, Talmadge E., Jr. ;
Lancaster, Lisa ;
Sahn, Steven A. ;
Szwarcberg, Javier ;
Valeyre, Dominique ;
du Bois, Roland M. .
LANCET, 2011, 377 (9779) :1760-1769
[10]   A Placebo-Controlled Randomized Trial of Warfarin in Idiopathic Pulmonary Fibrosis [J].
Noth, Imre ;
Anstrom, Kevin J. ;
Calvert, Sara Bristol ;
de Andrade, Joao ;
Flaherty, Kevin R. ;
Glazer, Craig ;
Kaner, Robert J. ;
Olman, Mitchell A. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :88-95