Travelling gradients in interacting morphogen systems

被引:18
作者
Baker, R. E.
Maini, P. K.
机构
[1] Univ Oxford, Ctr Math Biol, Math Inst, Oxford OX1 3QU, England
[2] Oxfor Ctr Integrative Syst Biol, Dept Biochem, Oxford OX1 3QU, England
关键词
morphogen gradients; mathematical modelling; FGF8; retinoic acid; segmentation;
D O I
10.1016/j.mbs.2007.01.006
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood. In this work, we investigate whether the presence of a secondary morphogen can increase the robustness of the primary morphogen gradient to perturbation, thereby providing a more stable mechanism for development. We base our model around the interactions of Fibroblast Growth Factor 8 and retinoic acid, which have been shown to act as morphogens in many developmental systems. In particular, we investigate the formation of opposing gradients of these morphogens along the antero-posterior axis of vertebrate embryos, thereby controlling temporal and spatial aspects of axis segmentation and neuronal differentiation. (C) 2007 Elsevier Inc. All rights reserved.
引用
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页码:30 / 50
页数:21
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