Gold(I)-catalyzed hydroaminative cyclization leading to 2,5-dihydroisoxazole

被引：43
作者：
Yeom, Hyun-Suk [1 ]
Lee, Eun-Sun [1 ]
Shin, Seunghoon [1 ]
机构：
[1] Hanyang Univ, Dept Chem, Seoul 133791, South Korea
来源：
SYNLETT | 2007年 / 14期
关键词：
2,5-dihydroisoxazoles; heterocycles; cyclizations gold catalysis; carbenoids;
D O I：
10.1055/s-2007-985571
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Gold(I)-catalyzed intramolecular hydroamination of O-propargyl-N-Boc-hydroxylamine is reported. The present method provides a novel, catalytic, and mild approach to 2,5-dihydroisoxazole derivatives. In addition, a mechanism of N-O cleavage as a side reaction as well as desired cyclization is proposed.
引用
收藏
页码：2292 / 2294
页数：3
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