Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics

被引:11
作者
Below, Jennifer E. [1 ]
Parra, Esteban J. [2 ]
机构
[1] Univ Texas Sch Publ Hlth, Ctr Human Genet, Houston, TX USA
[2] Univ Toronto, Dept Anthropol, Mississauga, ON L5L 1C6, Canada
关键词
Type; 2; diabetes; Lipids; Genome-wide studies; Hispanics; GENETICALLY COMPLEX TRAITS; MAJOR SUSCEPTIBILITY LOCUS; EXOME CHIP VARIANTS; LOW-FREQUENCY; LINKAGE STRATEGIES; MEXICAN-AMERICANS; FASTING GLUCOSE; GUT MICROBIOTA; RARE VARIANTS; STARR COUNTY;
D O I
10.1007/s11892-016-0737-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although disproportionately affected by increasing rates of type 2 diabetes and dyslipidemias, Hispanic populations are underrepresented in efforts to understand genetic susceptibility to these disorders. Where research has been undertaken, these populations have provided substantial insight into identification of novel risk-associated genes and have aided in the ability to fine map previously described risk loci. Genome-wide analyses in Hispanic and trans-ethnic populations have resulted in identification of more than 40 replicated or novel genes with significant effects for type 2 diabetes or lipid traits. Initial investigations into rare variant effects have identified new risk-associated variants private to Hispanic populations, and preliminary results suggest metagenomic approaches in Hispanic populations, such as characterizing the gut microbiome, will enable the development of new predictive tools and therapeutic targets for type 2 diabetes. Future genome-wide studies in expanded cohorts of Hispanics are likely to result in new insights into the genetic etiology of metabolic health.
引用
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页数:12
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