Effects of Parathyroid Hormone on Immune Function

被引:47
作者
Geara, Abdallah Sassine [1 ]
Castellanos, Mario R. [1 ]
Bassil, Claude [1 ]
Schuller-Levis, Georgia [2 ]
Park, Eunkue [2 ]
Smith, Marianne [1 ]
Goldman, Michael [3 ]
Elsayegh, Suzanne
机构
[1] Staten Isl Univ Hosp, Dept Med, Staten Isl, NY 10305 USA
[2] NYS Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA
[3] Staten Isl Univ Hosp, Div Nephrol, Staten Isl, NY 10305 USA
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2010年
关键词
CHRONIC-RENAL-FAILURE; OSTEOCLAST-ACTIVATING FACTOR; HEPATITIS-B VACCINATION; T-CELL PROLIFERATION; IMPAIRED PHAGOCYTOSIS; DIALYSIS PATIENTS; IMMUNOGLOBULIN PRODUCTION; RANDOM MIGRATION; UREMIC PATIENTS; HEMODIALYSIS;
D O I
10.1155/2010/418695
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis. Since the early 1980s, PTH receptors were found on most immunologic cells (neutrophils, B and T cells). The in vitro evaluations for a possible role of PTH as immunomodulator have shown inconsistent results mainly due to methodological heterogeneity of these studies: it used different PTH formulations (rat, bovine, and human), at different dosages and different incubating periods. In some of these studies, the lymphocytes were collected from uremic patients or animals, which renders the interpretation of the results problematic due to the effect of uremic toxins. Parathyroidectomy has been found to reverse the immunologic defect in patients with high PTH levels. Nonetheless, the clinical significance of these findings is unclear. Further studies are needed to define if PTH does have immunomodulatory effects.
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页数:10
相关论文
共 74 条
[11]   PRESENCE OF PREACTIVATED T-CELLS IN HEMODIALYZED PATIENTS - THEIR POSSIBLE ROLE IN ALTERED IMMUNITY [J].
CHATENOUD, L ;
DUGAS, B ;
BEAURAIN, G ;
TOUAM, M ;
DRUEKE, T ;
VASQUEZ, A ;
GALANAUD, P ;
BACH, JF ;
DELFRAISSY, JF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7457-7461
[12]   PRODUCTION OF OSTEOCLAST-ACTIVATING FACTOR BY NORMAL HUMAN PERIPHERAL-BLOOD ROSETTING AND NON-ROSETTING LYMPHOCYTES [J].
CHEN, P ;
TRUMMEL, C ;
HORTON, J ;
BAKER, JJ ;
OPPENHEIM, JJ .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1976, 6 (10) :732-736
[13]   IMPAIRED PHAGOCYTOSIS IN CHRONIC-RENAL-FAILURE IS MEDIATED BY SECONDARY HYPERPARATHYROIDISM [J].
CHERVU, I ;
KIERSZTEJN, M ;
ALEXIEWICZ, JM ;
FADDA, GZ ;
SMOGORZEWSKI, M ;
MASSRY, SG .
KIDNEY INTERNATIONAL, 1992, 41 (06) :1501-1505
[14]   Neutrophil dysfunction and infection risk in end-stage renal disease [J].
Chonchol, Michel .
SEMINARS IN DIALYSIS, 2006, 19 (04) :291-296
[15]  
Cohen G, 1997, KIDNEY INT, V52, pS79
[16]   MONOCLONAL IGG GAMMOPATHY AND HYPERPARATHYROIDISM [J].
DEXTER, RN ;
WILLIAMS, RC ;
MULLINAX, F ;
ESTEP, HL .
ANNALS OF INTERNAL MEDICINE, 1972, 77 (05) :759-+
[17]   EFFECT OF PARATHYROID-HORMONE ON RANDOM MIGRATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].
DOHERTY, CC ;
LABELLE, P ;
COLLINS, JF ;
BRAUTBAR, N ;
MASSRY, SG .
AMERICAN JOURNAL OF NEPHROLOGY, 1988, 8 (03) :212-219
[18]   Disturbances of acquired immunity in hemodialysis patients [J].
Eleftheriadis, Theodoros ;
Antoniadi, Georgia ;
Liakopoulos, Vassilios ;
Kartsios, Charalambos ;
Stefanidis, Loannis .
SEMINARS IN DIALYSIS, 2007, 20 (05) :440-451
[19]   TOXICITY IN UREMIA .2. CORRELATION BETWEEN PTH LEVELS AND IMPAIRED ASPECIFIC IMMUNITY [J].
ESPOSITO, R ;
ROMANOCARRATELLI, C ;
LANZETTI, N ;
HOHENEGGER, M ;
PLUVIO, M ;
CAPODICASA, G ;
NUZZO, I ;
GIORDANO, C .
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 1988, 11 (03) :159-160
[20]   INTACT ANTIBODY-RESPONSE TO PNEUMOCOCCAL CAPSULAR POLYSACCHARIDES IN UREMIA AND DIABETES [J].
FRIEDMAN, EA ;
BEYER, MM ;
HIRSCH, SR ;
SCHIFFMAN, G .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1980, 244 (20) :2310-2311