Rethinking schizophrenia

被引:1333
作者
Insel, Thomas R. [1 ]
机构
[1] NIMH, Bethesda, MD 20892 USA
关键词
CHILDHOOD-ONSET SCHIZOPHRENIA; ULTRA-HIGH RISK; FOLLOW-UP; OBSTETRIC COMPLICATIONS; ADULT SCHIZOPHRENIA; PSYCHOTIC DISORDERS; PRENATAL EXPOSURE; BRAIN-DEVELOPMENT; DEFICITS; GENES;
D O I
10.1038/nature09552
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently disabling mental disorder that affects about one per cent of the world's population. After a century of studying schizophrenia, the cause of the disorder remains unknown. Treatments, especially pharmacological treatments, have been in wide use for nearly half a century, yet there is little evidence that these treatments have substantially improved outcomes for most people with schizophrenia. These current unsatisfactory outcomes may change as we approach schizophrenia as a neurodevelopmental disorder with psychosis as a late, potentially preventable stage of the illness. This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades.
引用
收藏
页码:187 / 193
页数:7
相关论文
共 99 条
[52]   A separate disease within the syndrome of schizophrenia [J].
Kirkpatrick, B ;
Buchanan, RW ;
Ross, DE ;
Carpenter, WT .
ARCHIVES OF GENERAL PSYCHIATRY, 2001, 58 (02) :165-171
[53]   The NIMH-MATRICS consensus statement on negative symptoms [J].
Kirkpatrick, B ;
Fenton, WS ;
Carpenter, WT ;
Marder, SR .
SCHIZOPHRENIA BULLETIN, 2006, 32 (02) :214-219
[54]  
Kraepelin E., 1971, DEMENTIA PRAECOX PAR
[55]   Cognitive decline in schizophrenia from childhood to midlife: A 33-year longitudinal birth cohort study [J].
Kremen, William S. ;
Vinogradov, Sophia ;
Poole, John H. ;
Schaefer, Catherine A. ;
Deicken, Raymond F. ;
Factor-Litvak, Pam ;
Brown, Alan S. .
SCHIZOPHRENIA RESEARCH, 2010, 118 (1-3) :1-5
[56]  
Lambe EK, 2000, J NEUROSCI, V20, P8780
[57]   Schizophrenia as a disorder of neurodevelopment [J].
Lewis, DA ;
Levitt, P .
ANNUAL REVIEW OF NEUROSCIENCE, 2002, 25 :409-432
[58]   Neuroplasticity of neocortical circuits in schizophrenia [J].
Lewis, David A. ;
Gonzalez-Burgos, Guillermo .
NEUROPSYCHOPHARMACOLOGY, 2008, 33 (01) :141-165
[59]   Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice [J].
Li, Weidong ;
Zhou, Yu ;
Jentsch, J. David ;
Brown, Robert A. M. ;
Tian, Xiaoli ;
Ehninger, Dan ;
Hennah, William ;
Peltonen, Leena ;
Lonnqvist, Jouko ;
Huttunen, Matti O. ;
Kaprio, Jaakko ;
Trachtenberg, Joshua T. ;
Silva, Alcino J. ;
Cannon, Tyrone D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (46) :18280-18285
[60]   Effectiveness of antipsychotic drugs in patients with chronic schizophrenia [J].
Lieberman, JA ;
Stroup, TS ;
McEvoy, JP ;
Swartz, MS ;
Rosenheck, RA ;
Perkins, DO ;
Keefe, RSE ;
Davis, SM ;
Davis, CE ;
Lebowitz, BD ;
Severe, J ;
Hsiao, JK .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (12) :1209-1223