Boosting the Anticancer Activity of Sunitinib Malate in Breast Cancer through Lipid Polymer Hybrid Nanoparticles Approach

被引：31
作者：
Ahmed, Mohammed Muqtader [1 ]
Anwer, Md. Khalid [1 ]
Fatima, Farhat [1 ]
Aldawsari, Mohammed F. [1 ]
Alalaiwe, Ahmed [1 ]
Alali, Amer S. [1 ]
Alharthi, Abdulrahman I. [2 ]
Abul Kalam, Mohd [3 ,4 ]
机构：
[1] Prince Sattam Bin Abdulaziz Univ, Dept Pharmaceut, Coll Pharm, POB 173, Al Kharj 11942, Saudi Arabia
[2] Prince Sattam Bin Abdulaziz Univ, Coll Sci & Humanities, Dept Chem, POB 83, Al Kharj 11942, Saudi Arabia
[3] King Saud Univ, Coll Pharm, Nanobiotechnol Res Unit, POB 2457, Riyadh 11451, Saudi Arabia
[4] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh 11451, Saudi Arabia
来源：
POLYMERS | 2022年 / 14卷 / 12期
关键词：
sunitinib; lipoid; 90H; chitosan; nanoparticles; breast cancer; caspase; TYROSINE KINASE INHIBITOR; PLGA NANOPARTICLES; LOADED PLGA; FORMULATION; DELIVERY; CELLS; GENE;
D O I：
10.3390/polym14122459
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In the current study, lipid-polymer hybrid nanoparticles (LPHNPs) fabricated with lipoid-90H and chitosan, sunitinib malate (SM), an anticancer drug was loaded using lecithin as a stabilizer by employing emulsion solvent evaporation technique. Four formulations (SLPN1-SLPN4) were developed by varying the concentration of chitosan polymer. Based on particle characterization, SLPN4 was optimized with size (439 +/- 5.8 nm), PDI (0.269), ZP (+34 +/- 5.3 mV), and EE (83.03 +/- 4.9%). Further, the optimized formulation was characterized by FTIR, DSC, XRD, SEM, and in vitro release studies. In-vitro release of the drug from SPN4 was found to be 84.11 +/- 2.54% as compared with pure drug SM 24.13 +/- 2.67%; in 48 h, release kinetics followed the Korsmeyer-Peppas model with Fickian release mechanism. The SLPN4 exhibited a potent cytotoxicity against MCF-7 breast cancer, as evident by caspase 3, 9, and p53 activities. According to the findings, SM-loaded LPHNPs might be a promising therapy option for breast cancer.
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页数：15
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