Structure and properties of microcellulose-based coatings deposited via a low-energy electron beam and their effect on the properties of onto wound dressings

被引：4
作者：
Liu, Yiming [1 ,2 ]
Qin, Xu [1 ]
Rogachev, A., V [1 ,2 ]
Rogachev, A. A. [1 ,3 ]
Kontsevaya, I. I. [2 ]
Pyzh, A. E. [4 ]
Jiang, Xiaohong [1 ]
Yarmolenko, V. A. [5 ]
Rudenkov, A. S. [1 ,2 ]
Yarmolenko, M. A. [1 ,2 ]
机构：
[1] Nanjing Univ Sci & Technol, Int Chinese Belorussian Sci Lab Vacuum Plasma Tec, 200 Xiaolingwei St, Nanjing 210094, Peoples R China
[2] Francisk Skorina Gomel State Univ, 104 Sovetskaya St, Gomel 246019, BELARUS
[3] Natl Acad Sci Belarus, Inst Chem New Mat, 36 F Skoriny, Minsk 220141, BELARUS
[4] Natl Acad Sci Belarus, Inst Physiol, 28 Acad Skaya St, Minsk 220072, BELARUS
[5] Gomel State Med Univ, 5 Lange St, Gomel 246000, BELARUS
来源：
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS | 2021年 / 2卷
关键词：
Electron-beam deposition; Microcrystalline cellulose; Miramistin; P2O5; Molecular structure; Drug release; Dressing material; Prolonged antibacterial and antifungal properties; CELLULOSE; COMPOSITE; FEATURES; CALCIUM;
D O I：
10.1016/j.carpta.2021.100146
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The molecular structure and properties of a three-layer system based on CaH2, P2O5, microcrystalline cellulose + miramistin deposited via a low-energy electron beam onto a wound dressing have been considered. A crosslinked cellulose layer containing carbon particles and a drug component serves as the coating. The crosslinked structure of the coating enhances the resistance of the miramistin to thermal degradation. The high sorption activity of the gauze substrate determines the exponential nature of the change in the miramistin concentration in the solution. The deposition of a three-layer coating (CaH2 + P2O5 + (cellulose + miramistin)) allows imparting prolonged antibacterial (E. coli, S. aureus) and antifungal (C. alibicans) properties to gauze dressings, reducing the rate of moisture desorption from its volume as a result of the hydrogel formation on the surface of the fibers. Here, the hydrogel formation affects the decrease (over two times) in the gauze's ability to sorb moisture.
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页数：11
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