Palladium-catalyzed allylic amination: a powerful tool for the enantioselective synthesis of acyclic nucleoside phosphonates

被引：8

作者：

Azzouz, Mariam ^{[1
]}

Soriano, Sebastien ^{[1
]}

Escudero-Casao, Margarita ^{[1
]}

Isabel Matheu, M. ^{[1
]}

Castillon, Sergio ^{[1
]}

Diaz, Yolanda ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Fac Quim, Dept Quim Analit & Quim Organ, C Marcel Li Domingo 1, Tarragona 43007, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 34期

关键词：

RING-CLOSING METATHESIS; ALPHA; BETA-UNSATURATED KETONES; CROSS-METATHESIS; FORMAL SYNTHESIS; HETEROCYCLES; CARBANUCLEOSIDES; DERIVATIVES; COMPLEXES; EFFICIENT; STRATEGY;

D O I：

10.1039/c7ob01478c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate.

引用

页码：7227 / 7234

页数：8

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