Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats

被引：5

作者：

Zsolt Kovacs ^{[1
]}

Andras Czurko ^{[2
,3
]}

Kekesi, Katalin A. ^{[2
,4
]}

Gabor Juhasz ^{[2
]}

机构：

[1] Univ W Hungary, Dept Zool, H-9700 Budapest, Hungary

[2] Eotvos Lorand Univ, Lab Prote, H-1117 Budapest, Hungary

[3] Univ Szeged, Inst Med Chem, H-6720 Szeged, Hungary

[4] Eotvos Lorand Univ, Dept Physiol & Neurobiol, H-1117 Budapest, Hungary

来源：

EPILEPSY RESEARCH | 2010年 / 90卷 / 1-2期

关键词：

Absence epilepsy; Clomipramine; WAG/Rij rats; ABSENCE EPILEPSY; GENERALIZED ABSENCE; RECEPTORS; SEIZURES; MODEL; 5-HT1A; NEUROTRANSMISSION; REDUCTION; 8-OH-DPAT; INHIBIT;

D O I：

10.1016/j.eplepsyres.2010.02.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Methods: We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4 h after injection. The changes in SWDs were compared to the preceding 5-day average control level. Results: The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period. Conclusions: Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：167 / 170

页数：4

共 24 条

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