Does serum 25 hydroxy vitamin D level predict disease activity in ulcerative colitis patients?

被引:21
作者
Dolatshahi, Shahab [1 ]
Pishgar, Elham [1 ]
Jamali, Raika [1 ,2 ]
机构
[1] Univ Tehran Med Sci, Sina Hosp, Dept Internal Med, Tehran, Iran
[2] Univ Tehran Med Sci, Sina Hosp, Res Dev Ctr, Tehran, Iran
关键词
Ulcerative colitis; Inflammatory bowel disease; Vitamin D; Measurement; INFLAMMATORY-BOWEL-DISEASE; D DEFICIENCY; ASSOCIATION;
D O I
10.1080/17843286.2015.1110895
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aim: There are controversial results regarding the relationship of serum 25 hydroxy vitamin D [25(OH)D] and ulcerative colitis (UC) activity. To address this issue, the current study was designed to evaluate the correlation of serum 25(OH)D level and disease activity in patients with UC. Method: All consecutively selected UC outpatients referred to a gastroenterology clinic were enrolled in 2014. UC was diagnosed based on clinical, colonoscopic and histologic findings by a gastroenterologist. The exclusion criteria consisted of the factors that might influence plasma 25(OH)D concentration including inadequate exposure or intake, reduced absorption and abnormal metabolism. Disease activity was assessed by 'Truelove and Witts' classification'. Results: Fifty UC patients with mean age of 36.98 (+/- 11.81) years were evaluated. Mean serum 25(OH)D concentrations were significantly higher in 'mild disease activity' group (27.06 +/- 6.56 ng/ml) than 'moderate disease activity' group (11.14 +/- 4.03 ng/ml). Lower serum 25(OH)D concentration was associated with an increased likelihood of exhibiting moderate disease activity [beta = 0.37, 95% confidence interval (CI): 0.15-0.94, p value = 0.04]. Conclusion: Lower serum 25(OH)D level might be associated with higher disease activity in UC patients with mild-to-moderate activity.
引用
收藏
页码:46 / 50
页数:5
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