Sleeve Gastrectomy Decreases Body Weight, Whole-Body Adiposity, and Blood Pressure Even in Aged Diet-Induced Obese Rats

被引：13

作者：

Moncada, Rafael ^{[1
,2
,4
]}

Rodriguez, Amaia ^{[1
,2
,3
]}

Becerril, Sara ^{[1
,2
,3
]}

Mendez-Gimenez, Leire ^{[1
,2
,3
]}

Valenti, Victor ^{[1
,2
,5
]}

Ramirez, Beatriz ^{[1
,2
,3
]}

Cienfuegos, Javier A. ^{[1
,2
,5
]}

Fernandez, Secundino ^{[1
,2
,6
]}

Catalan, Victoria ^{[1
,2
,3
]}

Gomez-Ambrosi, Javier ^{[2
,3
]}

Fruhbeck, Gema ^{[1
,2
,3
,7
]}

机构：

[1] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain

[2] Inst Invest Sanitario Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain

[3] Univ Navarra Clin, Metab Res Lab, Avda Pio 12,36, Pamplona 31008, Spain

[4] Univ Navarra Clin, Dept Anesthesia, Avda Pio 12,36, Pamplona 31008, Spain

[5] Univ Navarra Clin, Dept Surg, Avda Pio 12,36, Pamplona 31008, Spain

[6] Univ Navarra Clin, Dept Otorhinolaryngol, Avda Pio 12,36, Pamplona 31008, Spain

[7] Univ Navarra Clin, Dept Endocrinol & Nutr, Avda Pio 12,36, Pamplona 31008, Spain

来源：

OBESITY SURGERY | 2016年 / 26卷 / 07期

关键词：

Sleeve gastrectomy; Experimental models of bariatric surgery; Aging; Diet-inducedobesity; Hypertension; BARIATRIC SURGERY; GHRELIN CONCENTRATIONS; GLUCOSE-HOMEOSTASIS; PRACTICE GUIDELINES; INSULIN-RESISTANCE; OREXIGENIC ACTION; GASTRIC BYPASS; RISK-FACTOR; LEPTIN; ASSOCIATION;

D O I：

10.1007/s11695-015-1919-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Aging and obesity are two conditions associated with increased risk of cardiovascular disease. Our aim was to analyze whether an advanced age affects the beneficial effects of sleeve gastrectomy on weight loss and blood pressure in an experimental model of diet-induced obesity (DIO). Young (6-month-old) and old (18-month-old) male Wistar DIO rats (n = 101) were subjected to surgical (sham operation and sleeve gastrectomy) or dietary interventions (pair-fed to the amount of food eaten by sleeve gastrectomized animals). Systolic (SBP), diastolic (DBP), and mean (MBP) blood pressure values and heart rate (HR) were recorded in conscious, resting animals by non-invasive tail-cuff plethysmography before and 4 weeks after surgical or dietary interventions. Aging was associated with higher (P < 0.05) body weight and subcutaneous and perirenal fat mass as well as mild cardiac hypertrophy. Sleeve gastrectomy induced a reduction in body weight, whole-body adiposity, and serum total ghrelin in both young and old DIO rats. The younger group achieved a higher excess weight loss than the older group (164 +/- 60 vs. 82 +/- 17 %, P < 0.05). A significant (P < 0.05) decrease in insulin resistance, SBP, DBP, MBP, and HR without changes in heart weight was observed after sleeve gastrectomy independently of age. Our results provide evidence for the effectiveness of sleeve gastrectomy without increased operative risk in body weight and blood pressure reduction even in aged animals via endocrine changes that go beyond the mere caloric restriction.

引用

页码：1549 / 1558

页数：10