Estimating the risks and benefits before salvage surgery for recurrent head and neck squamous cell carcinoma

Introduction: The risks associated with salvage surgery of head and neck squamous cell carcinoma (SCC) in a previously irradiated field needs to be balanced against the expected survival benefits. We want to identify preoperative predictive factors for overall and disease-specific survival (OS/DSS) and for the development of serious (Clavien-Dindo, CD>III) complications following salvage surgery for radio-recurrent SCC to help surgeons, patients, and caregivers in the decision-making process in this setting. Materials and methods: The records of 234 patients presenting to the Lorraine Cancer Institute with locoregional radiorecurrent SCC were reviewed. The primary endpoint was OS, secondary endpoints were DSS, OS without tracheostomy/gastrostomy, and the risk of CD>III complications. Multivariate analyses were carried out to explore preoperative factors associated with survival and the risk of post -operative complications. Results: With a median follow-up time of 19 months, 5-year OS since the first salvage surgery was 28.3%, 5-year DSS was 38.9%. 2-and 5-year functional OS were 45.6% and 27.2%. rcT-rcN, and WUNHCI >4 were both independent significant preoperative predictors of OS and DSS. 30-days postoperative complica-tions occurred in 44.4% of patients (28 CD I, 24 CD II, 34 CD III, 11 CD IV, 7 CD V). A salvage procedure involving T+N plus the presence of a WUHNCI >4 was the only independent predictor of CD>III complications. Conclusion: When discussing with the patients and the caregivers salvage surgery for recurrent head and neck SCC, a careful evaluation of the preoperative comorbidities by the WUHNCI tool can reliably predict the expected risks and benefits from the procedure. (c) 2021 Elsevier Ltd, BASO -The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.